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    toe twin of eyg [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39418, updated on 4-Jan-2025

    Summary

    Official Symbol
    toeprovided by FlyBase
    Official Full Name
    twin of eygprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036285
    Locus tag
    Dmel_CG10704
    See related
    AllianceGenome:FB:FBgn0036285
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0172774.89; CG10704; Dmel\CG10704; Toe; TOE
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in compound eye development and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including epithelium; imaginal disc; sense organ; sensory cluster; and sensory nervous system primordium. [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See toe in Genome Data Viewer
    Location:
    69C1-69C1; 3-38 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12422510..12432668, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12415610..12425768, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Short Calcium-binding Mitochondrial Carrier Neighboring gene ADP-ribosylation factor GTPase activating protein 1 Neighboring gene eyegone Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    twin of eyg
    Names
    CG10704-PA
    CG10704-PB
    toe-PA
    toe-PB
    twin of eyegone

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12422510..12432668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274833.1 → NP_001261762.1  twin of eyg, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261762.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFA4
      Conserved Domains (3) summary
      COG5576
      Location:346 → 429
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam00046
      Location:388 → 430
      Homeobox; Homeobox domain
      cl21459
      Location:134 → 230
      HTH; Helix-turn-helix domains
    2. NM_079317.3 → NP_524041.2  twin of eyg, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524041.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0M4, Q9VTX6
      Related
      FBpp0075712
      Conserved Domains (2) summary
      pfam00046
      Location:388 → 440
      Homeobox; Homeobox domain
      cl21459
      Location:134 → 230
      HTH; Helix-turn-helix domains
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