Herc4 HECT and RLD domain containing E3 ubiquitin ligase 4 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Herc4provided by FlyBase
Official Full Name: HECT and RLD domain containing E3 ubiquitin ligase 4provided by FlyBase
Primary source: FLYBASE:FBgn0035207
Locus tag: Dmel_CG9153
See related: AllianceGenome:FB:FBgn0035207
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9153; dherc4; Dmel\CG9153; FBgn0035207; herc4; NM_167868.1; sherpa; Sherpa
Summary: Enables ubiquitin protein ligase activity. Involved in several processes, including positive regulation of antimicrobial peptide production; protein ubiquitination; and regulation of signal transduction. Located in cytoplasmic side of plasma membrane. Is expressed in several structures, including adult fat body; adult gut; adult head; ovary; and spermatozoon. Orthologous to several human genes including HERC3 (HECT and RLD domain containing E3 ubiquitin protein ligase 3) and HERC4 (HECT and RLD domain containing E3 ubiquitin protein ligase 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 61F6-61F6; 3-0 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (1313696..1318330)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (1313696..1318330)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Toll signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of Toll signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antimicrobial peptide production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: HECT and RLD domain containing E3 ubiquitin ligase 4

Names: CG9153-PA; CG9153-PB; CG9153-PC; HECT and RLD domain containing E3 ligase; Herc4-PA; Herc4-PB; Herc4-PC; SUMO-related HECT domain and RCC repeat protein for toll pathway activation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

1313696..1318330

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_167868.2 → NP_728591.1 HECT and RLD domain containing E3 ubiquitin ligase 4, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728591.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MQN4, Q9W0H2

Related

FBpp0072564

Conserved Domains (4) summary

smart00119
Location:735 → 1055

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:711 → 1056

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

pfam00415
Location:268 → 317

RCC1; Regulator of chromosome condensation (RCC1) repeat

pfam13540
Location:304 → 334

RCC1_2; Regulator of chromosome condensation (RCC1) repeat
NM_001274320.1 → NP_001261249.1 HECT and RLD domain containing E3 ubiquitin ligase 4, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261249.1

Status: REVIEWED

UniProtKB/TrEMBL

E8NHA2, Q8MQN4

Conserved Domains (4) summary

smart00119
Location:739 → 1059

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:715 → 1060

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

pfam00415
Location:273 → 322

RCC1; Regulator of chromosome condensation (RCC1) repeat

pfam13540
Location:309 → 339

RCC1_2; Regulator of chromosome condensation (RCC1) repeat
NM_138254.3 → NP_612098.2 HECT and RLD domain containing E3 ubiquitin ligase 4, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_612098.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8MQN4, Q9W0H2

Related

FBpp0072563

Conserved Domains (4) summary

smart00119
Location:735 → 1055

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:711 → 1056

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

pfam00415
Location:268 → 317

RCC1; Regulator of chromosome condensation (RCC1) repeat

pfam13540
Location:304 → 334

RCC1_2; Regulator of chromosome condensation (RCC1) repeat