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    Mthfs Methenyltetrahydrofolate synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37699, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mthfsprovided by FlyBase
    Official Full Name
    Methenyltetrahydrofolate synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0085453
    Locus tag
    Dmel_CG34424
    See related
    AllianceGenome:FB:FBgn0085453
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.139; CG11079; CG34424; Dmel\CG34424; MTHF
    Summary
    Predicted to enable 5-formyltetrahydrofolate cyclo-ligase activity. Predicted to be involved in folic acid-containing compound biosynthetic process and tetrahydrofolate interconversion. Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to human MTHFS (methenyltetrahydrofolate synthetase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mthfs in Genome Data Viewer
    Location:
    59D8-59D8; 2-102 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23359215..23360266)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19246738..19247789)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44168 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene virilizer Neighboring gene Interacts with the C terminus of ELL 1 Neighboring gene Golgin-245 Neighboring gene uncharacterized protein Neighboring gene yellow-d

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DASH-type cryptochromes - solved and open questions. Kiontke S, et al. Biol Chem, 2020 Nov 26. PMID 32663167
    2. RNAi screening of Drosophila (Sophophora) melanogaster S2 cells for ricin sensitivity and resistance. Pawar V, et al. J Biomol Screen, 2011 Apr. PMID 21364088, Free PMC Article
    3. Differential gene expression related to Nora virus infection of Drosophila melanogaster. Cordes EJ, et al. Virus Res, 2013 Aug. PMID 23603562, Free PMC Article
    4. Towards comprehensive annotation of Drosophila melanogaster enzymes in FlyBase. Garapati PV, et al. Database (Oxford), 2019 Jan 1. PMID 30689844, Free PMC Article
    5. Drosophila anti-nematode and antibacterial immune regulators revealed by RNA-Seq. Castillo JC, et al. BMC Genomics, 2015 Jul 11. PMID 26162375, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 5-formyltetrahydrofolate cyclo-ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5-formyltetrahydrofolate cyclo-ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in folic acid-containing compound biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in folic acid-containing compound biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tetrahydrofolate interconversion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    methenyltetrahydrofolate synthetase
    Names
    CG34424-PA
    CG34424-PB
    Mthfs-PA
    Mthfs-PB
    NP_001097432.1
    NP_001286765.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23359215..23360266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103962.4 → NP_001097432.1  methenyltetrahydrofolate synthetase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097432.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9XQB1, Q8MLS1
      Conserved Domains (1) summary
      cl00360
      Location:10 → 201
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family

    2. NM_001299836.1 → NP_001286765.1  methenyltetrahydrofolate synthetase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286765.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9XQB1, Q8MLS1
      Conserved Domains (1) summary
      cl00360
      Location:10 → 201
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MLS1 Q8MLS1

    Gene LinkOut

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