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    Gmppa GDP-mannose pyrophosphorylase A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36730, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gmppaprovided by FlyBase
    Official Full Name
    GDP-mannose pyrophosphorylase Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034035
    Locus tag
    Dmel_CG8207
    See related
    AllianceGenome:FB:FBgn0034035
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8207; Dmel\CG8207
    Summary
    Predicted to enable enzyme inhibitor activity. Predicted to be involved in GDP-mannose metabolic process. Predicted to be part of GDP-mannose pyrophosphorylase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; circulatory system primordium; embryonic/larval midgut primordium; gut section; and mesoderm. Human ortholog(s) of this gene implicated in alacrima, achalasia, and impaired intellectual development syndrome. Orthologous to human GMPPA (GDP-mannose pyrophosphorylase A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gmppa in Genome Data Viewer
    Location:
    52B5-52B5; 2-75 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15677218..15678956, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11564723..11566461, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mir-278 stem loop Neighboring gene fusilli Neighboring gene antisense RNA:CR45143 Neighboring gene Vacuolar H[+] ATPase 14kD subunit 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. fusilli, an essential gene with a maternal role in Drosophila embryonic dorsal-ventral patterning. Wakabayashi-Ito N, et al. Dev Biol, 2001 Jan 1. PMID 11133153
    2. Adaptation to Chronic Nutritional Stress Leads to Reduced Dependence on Microbiota in Drosophila melanogaster. Erkosar B, et al. mBio, 2017 Oct 24. PMID 29066546, Free PMC Article
    3. The impact of genome variation and diet on the metabolic phenotype and microbiome composition of Drosophila melanogaster. Jehrke L, et al. Sci Rep, 2018 Apr 18. PMID 29670218, Free PMC Article
    4. The Drosophila Helicase Maleless (MLE) is Implicated in Functions Distinct From its Role in Dosage Compensation. Cugusi S, et al. Mol Cell Proteomics, 2015 Jun. PMID 25776889, Free PMC Article
    5. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables enzyme inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT enables mannose-1-phosphate guanylyltransferase (GTP) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP-mannose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GDP-mannose pyrophosphorylase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GDP-mannose pyrophosphorylase A
    Names
    CG8207-PA
    Gmppa-PA
    NP_611051.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15677218..15678956 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137207.4 → NP_611051.2  GDP-mannose pyrophosphorylase A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611051.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SXU3, Q9V7E1
      Related
      FBpp0086475
      Conserved Domains (3) summary
      cd06428
      Location:4 → 270
      M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
      COG1208
      Location:1 → 366
      GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
      cl00160
      Location:306 → 372
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SXU3 Q8SXU3

    Gene LinkOut

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