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    ttm3 tiny tim 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35437, updated on 9-Dec-2024

    Summary

    Official Symbol
    ttm3provided by FlyBase
    Official Full Name
    tiny tim 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0032971
    Locus tag
    Dmel_CG6691
    See related
    AllianceGenome:FB:FBgn0032971
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6691; Dmel\CG6691
    Summary
    Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Predicted to be involved in mitochondrial membrane organization; protein dephosphorylation; and protein import into mitochondrial matrix. Predicted to be located in mitochondrial inner membrane. Predicted to be part of TIM23 mitochondrial import inner membrane translocase complex. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 9. Orthologous to human TIMM50 (translocase of inner mitochondrial membrane 50). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See ttm3 in Genome Data Viewer
    Location:
    40E2-40E2; 2-54 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (22079632..22080738)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (22079632..22080738)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene testis-specific Plus3 domain a Neighboring gene testis-specific Plus3 domain b Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein serine/threonine phosphatase activity  
    enables protein tyrosine phosphatase activity  
    Process Evidence Code Pubs
    involved_in mitochondrial membrane organization  
    involved_in mitochondrion organization PubMed 
    involved_in protein dephosphorylation  
    involved_in protein import into mitochondrial matrix  
    Component Evidence Code Pubs
    part_of TIM23 mitochondrial import inner membrane translocase complex  
    part_of TIM23 mitochondrial import inner membrane translocase complex  
    located_in mitochondrial inner membrane  
    located_in mitochondrion PubMed 

    General protein information

    Preferred Names
    tiny tim 3
    Names
    CG6691-PA
    ttm3-PA
    NP_610130.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      22079632..22080738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136286.3 → NP_610130.1  tiny tim 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610130.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4QPP6, Q9V9P3
      UniProtKB/TrEMBL
      B5RJB0
      Related
      FBpp0085289
      Conserved Domains (2) summary
      smart00577
      Location:138 → 265
      CPDc; catalytic domain of ctd-like phosphatases
      pfam16515
      Location:276 → 332
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
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