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    Ranbp21 Ranbp21 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32970, updated on 17-Dec-2024

    Summary

    Official Symbol
    Ranbp21provided by FlyBase
    Official Full Name
    Ranbp21provided by FlyBase
    Primary source
    FLYBASE:FBgn0031051
    Locus tag
    Dmel_CG12234
    See related
    AllianceGenome:FB:FBgn0031051
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12234; Dmel\CG12234; dmExp5; Exp-5; Exp5; RanBP21
    Summary
    Predicted to enable RNA binding activity and nuclear export signal receptor activity. Predicted to be involved in RNA export from nucleus. Predicted to be part of RNA nuclear export complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in breast cancer; gastrointestinal system cancer (multiple); lung carcinoma (multiple); multiple myeloma; and primary ovarian insufficiency. Orthologous to human XPO5 (exportin 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Ranbp21 in Genome Data Viewer
    Location:
    18D12-18D13; 1-63 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19646306..19652269, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19540339..19546302, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Sec61 gamma subunit Neighboring gene Actin-related protein 10 Neighboring gene elys Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear export signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear export signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein export from nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of RNA nuclear export complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Ranbp21
    Names
    CG12234-PA
    CG12234-PB
    Exportin-5
    Exportin5
    Ranbp21-PA
    Ranbp21-PB
    exportin 5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19646306..19652269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298524.1NP_001285453.1  Ranbp21, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285453.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BP41, Q9VWE7
      Conserved Domains (2) summary
      pfam03810
      Location:34101
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:116274
      Xpo1; Exportin 1-like protein
    2. NM_134495.3NP_608339.2  Ranbp21, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608339.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BP41, Q9VWE7
      Related
      FBpp0074528
      Conserved Domains (2) summary
      pfam03810
      Location:34101
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:116274
      Xpo1; Exportin 1-like protein