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    dgt4 dim gamma-tubulin 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31361, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dgt4provided by FlyBase
    Official Full Name
    dim gamma-tubulin 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0026085
    Locus tag
    Dmel_CG4865
    See related
    AllianceGenome:FB:FBgn0026085
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:SD26403; CG4865; Dgt4; Dmel\CG4865; EG0007.10; EG:EG0007.10; msd3
    Summary
    Involved in mitotic spindle organization; mitotic spindle-templated microtubule nucleation; and regulation of mitotic nuclear division. Located in spindle. Part of HAUS complex. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dgt4 in Genome Data Viewer
    Location:
    4A6-4A6; 1-6 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4113701..4114929)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4007734..4008962)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene brainiac Neighboring gene ciboulot Neighboring gene NOP2-Sun domain family, member 2 Neighboring gene Tat interactive protein 60kDa Neighboring gene twenty-four Neighboring gene Glucuronyltransferase I

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in NSUN2 cause autosomal-recessive intellectual disability. Abbasi-Moheb L, et al. Am J Hum Genet, 2012 May 4. PMID 22541559, Free PMC Article
    2. A new Augmin subunit, Msd1, demonstrates the importance of mitotic spindle-templated microtubule nucleation in the absence of functioning centrosomes. Wainman A, et al. Genes Dev, 2009 Aug 15. PMID 19684111, Free PMC Article
    3. γ-TuRCs and the augmin complex are required for the development of highly branched dendritic arbors in Drosophila. Mukherjee A, et al. J Cell Sci, 2024 May 1. PMID 38606636, Free PMC Article
    4. Wac: a new Augmin subunit required for chromosome alignment but not for acentrosomal microtubule assembly in female meiosis. Meireles AM, et al. J Cell Biol, 2009 Mar 23. PMID 19289792, Free PMC Article
    5. Cross-linking mass spectrometry identifies new interfaces of Augmin required to localise the γ-tubulin ring complex to the mitotic spindle. Chen JWC, et al. Biol Open, 2017 May 15. PMID 28351835, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitotic spindle assembly IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle-templated microtubule nucleation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitotic spindle-templated microtubule nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of HAUS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dim gamma-tubulin 4
    Names
    CG4865-PA
    CG4865-PB
    CG4865-PC
    dgt4-PA
    dgt4-PB
    dgt4-PC
    mitotic spindle density 3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      4113701..4114929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272302.1 → NP_001259231.1  dim gamma-tubulin 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259231.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O97426, Q7K763, Q9W4M8

    2. NM_001272303.1 → NP_001259232.1  dim gamma-tubulin 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259232.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O97426, Q7K763, Q9W4M8

    3. NM_131922.3 → NP_572150.1  dim gamma-tubulin 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572150.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O97426, Q7K763, Q9W4M8
      Related
      FBpp0070610
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W4M8.1 Q9W4M8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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