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    Nxt1 NTF2-related export protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37769, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nxt1provided by FlyBase
    Official Full Name
    NTF2-related export protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0028411
    Locus tag
    Dmel_CG12752
    See related
    AllianceGenome:FB:FBgn0028411
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12752; Dmel\CG12752; dmNXT; dmNXT1; DmNXT1; dmP15; dNxt; dNxt1; Nxt; Nxt-1; nxt1; NXT1; p15
    Summary
    Involved in poly(A)+ mRNA export from nucleus. Located in cytoplasm; nuclear envelope; and nucleoplasm. Part of transcription repressor complex. Is expressed in several structures, including antennal primordium; embryonic/larval midgut primordium; gut section; head epidermis primordium; and mesoderm. Orthologous to human NXT1 (nuclear transport factor 2 like export factor 1) and NXT2 (nuclear transport factor 2 like export factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nxt1 in Genome Data Viewer
    Location:
    60A2-60A2; 2-105 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23811321..23811974, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19698844..19699497, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Structure specific recognition protein Neighboring gene antisense RNA:CR44807 Neighboring gene uncharacterized protein Neighboring gene pippin Neighboring gene Glycine transporter Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unravelling the general properties of siRNAs: strength in numbers and lessons from the past. Hall J. Nat Rev Genet, 2004 Jul. PMID 15211357
    2. Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes. Wiegand HL, et al. Mol Cell Biol, 2002 Jan. PMID 11739738, Free PMC Article
    3. RNA-binding proteins of the NXF (nuclear export factor) family and their connection with the cytoskeleton. Mamon LA, et al. Cytoskeleton (Hoboken), 2017 Apr. PMID 28296067
    4. Nuclear export of mRNA by TAP/NXF1 requires two nucleoporin-binding sites but not p15. Braun IC, et al. Mol Cell Biol, 2002 Aug. PMID 12101235, Free PMC Article
    5. MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Zeng Y, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12902540, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium HMP PubMed 
    involved_in negative regulation of innate immune response HMP PubMed 
    involved_in nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore central transport channel IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription repressor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NTF2-related export protein 1
    Names
    CG12752-PA
    CG12752-PB
    Nxt1-PA
    Nxt1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23811321..23811974 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137989.3 → NP_611833.1  NTF2-related export protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611833.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3H8
      UniProtKB/TrEMBL
      A0A1B2AKG3
      Related
      FBpp0072150
      Conserved Domains (1) summary
      cd00780
      Location:11 → 132
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    2. NM_001299854.1 → NP_001286783.1  NTF2-related export protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286783.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGG9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGG9 A0A0B4LGG9
    Q9V3H8.1 Q9V3H8

    Gene LinkOut

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