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    rib ribbon [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44855, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ribprovided by FlyBase
    Official Full Name
    ribbonprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003254
    Locus tag
    Dmel_CG7230
    See related
    AllianceGenome:FB:FBgn0003254
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7230; Dmel\CG7230; fus1; gene 5; Rib; RIB
    Summary
    Predicted to enable DNA-binding transcription factor activity. Involved in several processes, including embryonic morphogenesis; establishment or maintenance of epithelial cell apical/basal polarity; and open tracheal system development. Located in nucleus. Is expressed in several structures, including cardiogenic mesoderm; dorsal ectoderm; dorsal epidermis primordium; embryonic/larval midgut primordium; and epidermis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rib in Genome Data Viewer
    Location:
    56C6-56C6; 2-88 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19270078..19281396)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15157583..15168901)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44432 Neighboring gene testis-specifically expressed bromodomain containing protein-2 Neighboring gene uncharacterized protein Neighboring gene Arylalkylamine N-acetyltransferase-like 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kinetic and mechanical analysis of live tube morphogenesis. Cheshire AM, et al. Dev Dyn, 2008 Oct. PMID 18816822, Free PMC Article
    2. ribbon, raw, and zipper have distinct functions in reshaping the Drosophila cytoskeleton. Blake KJ, et al. Dev Genes Evol, 1999 Sep. PMID 10502112
    3. The genes raw and ribbon are required for proper shape of tubular epithelial tissues in Drosophila. Jack J, et al. Genetics, 1997 Sep. PMID 9286684, Free PMC Article
    4. The products of ribbon and raw are necessary for proper cell shape and cellular localization of nonmuscle myosin in Drosophila. Blake KJ, et al. Dev Biol, 1998 Nov 1. PMID 9806782
    5. Regulation of Gonad Morphogenesis in Drosophila melanogaster by BTB Family Transcription Factors. Silva D, et al. PLoS One, 2016. PMID 27898696, Free PMC Article

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ribbon boosts ribosomal protein gene expression to coordinate organ form and function.
      Title: Ribbon boosts ribosomal protein gene expression to coordinate organ form and function.
    2. Rib regulates cell growth and tissue shape in the Drosophila salivary gland.
      Title: Ribbon regulates morphogenesis of the Drosophila embryonic salivary gland through transcriptional activation and repression.
    3. These findings suggest that Ribbon and Lola Like function as a novel transcriptional cassette coordinating molecular changes at the apical membrane of epithelial cells to facilitate tube elongation.
      Title: Ribbon modulates apical membrane during tube elongation through Crumbs and Moesin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Malpighian tubule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell migration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in dorsal closure TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in epithelial cell migration, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in head involution IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hindgut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in membrane organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in open tracheal system development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in open tracheal system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of Malpighian tubule diameter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in salivary gland development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tracheal outgrowth, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribbon
    Names
    CG7230-PA
    CG7230-PB
    CG7230-PC
    SGP cluster fusion defects 1
    rib-PA
    rib-PB
    rib-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19270078..19281396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274155.1 → NP_001261084.1  ribbon, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261084.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KF43
      Conserved Domains (3) summary
      smart00225
      Location:44 → 133
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:33 → 133
      BTB; BTB/POZ domain
      pfam05225
      Location:373 → 417
      HTH_psq; helix-turn-helix, Psq domain

    2. NM_080534.4 → NP_536795.1  ribbon, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_536795.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KF43
      Related
      FBpp0085700
      Conserved Domains (3) summary
      smart00225
      Location:44 → 133
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:33 → 133
      BTB; BTB/POZ domain
      pfam05225
      Location:373 → 417
      HTH_psq; helix-turn-helix, Psq domain

    3. NM_001274156.2 → NP_001261085.1  ribbon, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261085.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFC4
      Conserved Domains (3) summary
      smart00225
      Location:44 → 133
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:33 → 133
      BTB; BTB/POZ domain
      pfam05225
      Location:373 → 417
      HTH_psq; helix-turn-helix, Psq domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFC4 A0A0B4KFC4
    Q7KF43 Q7KF43

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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