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    Mekk1 Mekk1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42253, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mekk1provided by FlyBase
    Official Full Name
    Mekk1provided by FlyBase
    Primary source
    FLYBASE:FBgn0024329
    Locus tag
    Dmel_CG7717
    See related
    AllianceGenome:FB:FBgn0024329
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7717; D-Mekk1; D-MEKK1; dMEKK; dMekk1; dMeKK1; dMEKK1; dMEKK4; Dmel\CG7717; DmMEKK1; MEKK; mekk1; MEKK1; Mekk1/4; mekk1a; mekk1b; MEKK4
    Summary
    Enables MAP kinase kinase kinase activity and mitogen-activated protein kinase kinase binding activity. Involved in several processes, including cellular hyperosmotic salinity response; engulfment of apoptotic cell; and intracellular signal transduction. Predicted to be located in cytoplasm. Is expressed in adult brain. Orthologous to human MAP3K4 (mitogen-activated protein kinase kinase kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mekk1 in Genome Data Viewer
    Location:
    91C5-91C5; 3-64 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18733106..18743594, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14558828..14569316, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Choline acetyltransferase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Phosphatidylglycerophosphate synthase 1 Neighboring gene greatwall

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inhalation toxicity of indoor air pollutants in Drosophila melanogaster using integrated transcriptomics and computational behavior analyses. Eom HJ, et al. Sci Rep, 2017 Jun 16. PMID 28621308, Free PMC Article
    2. GPCRs in invertebrate innate immunity. Reboul J, et al. Biochem Pharmacol, 2016 Aug 15. PMID 27262554
    3. A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK. Inoue H, et al. EMBO J, 2001 Oct 1. PMID 11574474, Free PMC Article
    4. Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila. Camilleri-Robles C, et al. Genes (Basel), 2019 May 18. PMID 31109086, Free PMC Article
    5. Paternal restraint stress affects offspring metabolism via ATF-2 dependent mechanisms in Drosophila melanogaster germ cells. Seong KH, et al. Commun Biol, 2020 May 4. PMID 32367035, Free PMC Article

    See all (118) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The CDK5 phosphorylates MEKK1, and together, they activate the JNK pathway for apoptosis.
      Title: CDK5 and MEKK1 mediate pro-apoptotic signalling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model.
    2. D-MEKK1, the fly orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediates the activation of D-JNK by cadmium and arsenite.
      Title: D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mitogen-activated protein kinase kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular hyperosmotic salinity response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to arsenic-containing substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to heat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in engulfment of apoptotic cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mucosal immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of negative regulation of heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in p38MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in p38MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell size IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription initiation-coupled chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Mekk1
    Names
    CG7717-PB
    CG7717-PD
    Mekk1-PB
    Mekk1-PD
    NP_650750.4
    NP_732373.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18733106..18743594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169833.2 → NP_732373.1  Mekk1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732373.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSQ4, Q95YH7
      Related
      FBpp0083099
      Conserved Domains (2) summary
      smart00220
      Location:1282 → 1541
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06626
      Location:1281 → 1542
      STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

    2. NM_142493.3 → NP_650750.4  Mekk1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650750.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95YH6, Q9VE37
      Conserved Domains (2) summary
      smart00220
      Location:1189 → 1448
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06626
      Location:1188 → 1449
      STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MSQ4 Q8MSQ4
    Q95YH6 Q95YH6
    Q95YH7 Q95YH7
    Q9VE37 Q9VE37

    Gene LinkOut

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