Kpna6 karyopherin subunit alpha 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kpna6provided by MGI
Official Full Name: karyopherin subunit alpha 6provided by MGI
Primary source: MGI:MGI:1100836
See related: Ensembl:ENSMUSG00000003731 AllianceGenome:MGI:1100836
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IPOA7; Kpna5; NPI-2
Summary: Enables nuclear import signal receptor activity. Acts upstream of or within several processes, including entry of viral genome into host nucleus through nuclear pore complex via importin; positive regulation of macromolecule biosynthetic process; and protein import into nucleus. Predicted to be located in host cell. Predicted to be part of NLS-dependent protein nuclear import complex. Predicted to be active in nucleoplasm. Is expressed in several structures, including gonad; heart; liver; lung; and spleen. Orthologous to human KPNA6 (karyopherin subunit alpha 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 30.4), subcutaneous fat pad adult (RPKM 16.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 63.28 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (129537772..129566560, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (129643979..129672767, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kpna6 deficiency causes infertility in male mice by disrupting spermatogenesis.
Title: Kpna6 deficiency causes infertility in male mice by disrupting spermatogenesis.
Data shows that Importin 7 binds many partners from ovary that alpha are involved in RNA processing, chromosome organization, and chromatin modification.
Title: Identification of importin α 7 specific transport cargoes using a proteomic screening approach.
Importin alpha7 is a new member of the small group of maternal effect genes.
Title: Importin α7 is essential for zygotic genome activation and early mouse development.
Overexpression of Kpna6 facilitates Keap1 nuclear import and attenuates Nrf2 signaling, whereas knockdown of Kpna6 slows down Keap1 nuclear import and enhances the Nrf2-mediated adaptive response induced by oxidative stress.
Title: KPNA6 (Importin {alpha}7)-mediated nuclear import of Keap1 represses the Nrf2-dependent antioxidant response.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (3)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear import signal receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within entry of viral genome into host nucleus through nuclear pore complex via importin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within entry of viral genome into host nucleus through nuclear pore complex via importin	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within maternal process involved in female pregnancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of viral life cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of viral life cycle	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within symbiont-mediated perturbation of host defenses	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within viral genome replication	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NLS-dependent protein nuclear import complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	NAS Non-traceable Author Statement more info	PubMed
located_in host cell	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	NAS Non-traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: importin subunit alpha-7

Names: importin alpha 7; importin alpha-S2; karyopherin (importin) alpha 5; karyopherin (importin) alpha 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008468.4 → NP_032494.3 importin subunit alpha-7

See identical proteins and their annotated locations for NP_032494.3

Status: VALIDATED

Source sequence(s)

AK046371, AL671759, CJ082540

Consensus CDS

CCDS18701.1

UniProtKB/Swiss-Prot

O35345, Q3U388, Q9CVP9

UniProtKB/TrEMBL

Q4FJZ2, Q8BH30

Related

ENSMUSP00000099650.5, ENSMUST00000102590.11

Conserved Domains (5) summary

COG5064
Location:36 → 525

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

cd00020
Location:251 → 365

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam01749
Location:9 → 102

IBB; Importin beta binding domain

pfam16186
Location:464 → 508

Arm_3; Atypical Arm repeat

sd00043
Location:254 → 279

ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

129537772..129566560 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006502814.4 → XP_006502877.1 importin subunit alpha-7 isoform X1

See identical proteins and their annotated locations for XP_006502877.1

UniProtKB/TrEMBL

Q4FJZ2

Related

ENSMUSP00000003828.5, ENSMUST00000003828.11

Conserved Domains (2) summary

COG5064
Location:41 → 530

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:259 → 284

ARM; armadillo repeat [structural motif]