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    Aspdh aspartate dehydrogenase domain containing [ Mus musculus (house mouse) ]

    Gene ID: 68352, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aspdhprovided by MGI
    Official Full Name
    aspartate dehydrogenase domain containingprovided by MGI
    Primary source
    MGI:MGI:1915602
    See related
    Ensembl:ENSMUSG00000038704 AllianceGenome:MGI:1915602
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610012D14Rik
    Summary
    Predicted to enable NADP binding activity and aspartate dehydrogenase activity. Predicted to be involved in NAD biosynthetic process. Orthologous to human ASPDH (aspartate dehydrogenase domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 186.3), kidney adult (RPKM 84.0) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Aspdh in Genome Data Viewer
    Location:
    7 B3; 7 28.83 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44114859..44117175)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44465435..44467751)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39002 Neighboring gene leucine rich repeat containing 4B Neighboring gene predicted gene, 39003 Neighboring gene STARR-positive B cell enhancer ABC_E9110 Neighboring gene Josephin domain containing 2 Neighboring gene microRNA 7052 Neighboring gene RIKEN cDNA 5430431A17 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    aspartate dehydrogenase domain-containing protein
    Names
    putative L-aspartate dehydrogenase
    NP_080966.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026690.1 → NP_080966.1  aspartate dehydrogenase domain-containing protein

      See identical proteins and their annotated locations for NP_080966.1

      Status: PROVISIONAL

      Source sequence(s)
      AK002587
      Consensus CDS
      CCDS21207.1
      UniProtKB/Swiss-Prot
      Q8VCQ0, Q9DCQ2
      UniProtKB/TrEMBL
      D3Z253
      Related
      ENSMUSP00000039202.5, ENSMUST00000035929.11
      Conserved Domains (2) summary
      pfam01958
      Location:176 → 265
      DUF108; Domain of unknown function DUF108
      pfam03447
      Location:17 → 127
      NAD_binding_3; Homoserine dehydrogenase, NAD binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44114859..44117175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCQ2.1 GenPept UniProtKB/Swiss-Prot:Q9DCQ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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