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    St6galnac5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 [ Mus musculus (house mouse) ]

    Gene ID: 26938, updated on 9-Dec-2024

    Summary

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    Official Symbol
    St6galnac5provided by MGI
    Official Full Name
    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5provided by MGI
    Primary source
    MGI:MGI:1349471
    See related
    Ensembl:ENSMUSG00000039037 AllianceGenome:MGI:1349471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Siat7e
    Summary
    Enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. Involved in glycosphingolipid biosynthetic process and oligosaccharide biosynthetic process. Predicted to be located in Golgi membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and respiratory system. Orthologous to human ST6GALNAC5 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 13.8), frontal lobe adult (RPKM 11.3) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See St6galnac5 in Genome Data Viewer
    Location:
    3 H3; 3 77.16 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (152525522..152687847, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (152819885..152982210, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class K Neighboring gene predicted gene, 40181 Neighboring gene ribosomal protein L29, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E3479 Neighboring gene predicted gene, 46830 Neighboring gene STARR-seq mESC enhancer starr_09299 Neighboring gene predicted gene, 40182 Neighboring gene predicted gene, 52620 Neighboring gene STARR-seq mESC enhancer starr_09300

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel glycosyltransferase with a polyglutamine repeat; a new candidate for GD1alpha synthase (ST6GalNAc V)(1). Ikehara Y, et al. FEBS Lett, 1999 Dec 10. PMID 10601645
    2. Molecular cloning of brain-specific GD1alpha synthase (ST6GalNAc V) containing CAG/Glutamine repeats. Okajima T, et al. J Biol Chem, 1999 Oct 22. PMID 10521438
    3. Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides. Tsuchida A, et al. J Biol Chem, 2003 Jun 20. PMID 12668675
    4. Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity. Paul A, et al. Cell, 2017 Oct 19. PMID 28942923, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ganglioside biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycosphingolipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oligosaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oligosaccharide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
    Names
    GD1 alpha synthase
    SIAT7-E
    ST6GalNAc V
    ST6GalNAcV
    galNAc alpha-2,6-sialyltransferase V
    sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) E
    sialyltransferase 7E
    NP_036158.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012028.5 → NP_036158.3  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5

      See identical proteins and their annotated locations for NP_036158.3

      Status: VALIDATED

      Source sequence(s)
      AC125349, AC162890
      Consensus CDS
      CCDS38676.1
      UniProtKB/Swiss-Prot
      Q9QYJ1, Q9R0K6
      UniProtKB/TrEMBL
      Q6GTI0, Q8CAM7, Q8CBX1
      Related
      ENSMUSP00000036227.6, ENSMUST00000044278.6
      Conserved Domains (1) summary
      pfam00777
      Location:87 → 308
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      152525522..152687847 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYJ1.1 GenPept UniProtKB/Swiss-Prot:Q9QYJ1

    Gene LinkOut

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