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    Zbtb26 zinc finger and BTB domain containing 26 [ Mus musculus (house mouse) ]

    Gene ID: 320633, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zbtb26provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 26provided by MGI
    Primary source
    MGI:MGI:2444402
    See related
    Ensembl:ENSMUSG00000050714 AllianceGenome:MGI:2444402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A630026F21Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Is expressed in placenta. Orthologous to human ZBTB26 (zinc finger and BTB domain containing 26). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.2), CNS E14 (RPKM 2.6) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zbtb26 in Genome Data Viewer
    Location:
    2 B; 2 24.19 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (37322180..37333184, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (37432168..37443172, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ring finger and CCCH-type zinc finger domains 2 Neighboring gene small nucleolar RNA, C/D box 90 Neighboring gene STARR-positive B cell enhancer ABC_E1244 Neighboring gene STARR-positive B cell enhancer ABC_E11130 Neighboring gene STARR-positive B cell enhancer ABC_E4442 Neighboring gene STARR-positive B cell enhancer ABC_E1004 Neighboring gene zinc finger and BTB domain containing 6 Neighboring gene RAB GTPase activating protein 1 Neighboring gene nucleoporin 37 pseudogene Neighboring gene G protein-coupled receptor 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ELAC2 Functions as a Key Gene in the Early Development of Placental Formation Based on WGCNA. Liang J, et al. Cells, 2023 Feb 14. PMID 36831280, Free PMC Article
    2. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Potential readthrough

    Included gene: Zbtb6

    Homology

    Clone Names

    • MGC130360, MGC130361

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 26
    Names
    zinc finger protein 483

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199025.3 → NP_950190.2  zinc finger and BTB domain-containing protein 26

      See identical proteins and their annotated locations for NP_950190.2

      Status: VALIDATED

      Source sequence(s)
      AL953890
      Consensus CDS
      CCDS16001.1
      UniProtKB/TrEMBL
      Q6P9Q3, Q8C8S0
      Related
      ENSMUSP00000070071.5, ENSMUST00000067043.5
      Conserved Domains (4) summary
      sd00017
      Location:300 → 320
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:298 → 320
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:23 → 123
      BTB; BTB/POZ domain
      pfam13465
      Location:315 → 337
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      37322180..37333184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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