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    Kansl3 KAT8 regulatory NSL complex subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 226976, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Kansl3provided by MGI
    Official Full Name
    KAT8 regulatory NSL complex subunit 3provided by MGI
    Primary source
    MGI:MGI:1918055
    See related
    Ensembl:ENSMUSG00000010453 AllianceGenome:MGI:1918055
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kiaa1310; mKIAA1310; 4932435K23; 4632411B12Rik
    Summary
    Predicted to be involved in positive regulation of transcription by RNA polymerase II and regulation of mitochondrial transcription. Part of NSL complex. Is expressed in 1-cell stage embryo; 2-cell stage embryo; 8-cell stage embryo; blastocyst; and brain. Orthologous to human KANSL3 (KAT8 regulatory NSL complex subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 24.1), adrenal adult (RPKM 14.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kansl3 in Genome Data Viewer
    Location:
    1 B; 1 15.22 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (36374811..36408276, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (36335730..36369193, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene neuralized E3 ubiquitin protein ligase 3 Neighboring gene STARR-positive B cell enhancer ABC_E3268 Neighboring gene STARR-positive B cell enhancer ABC_E2541 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:36364755-36365011 Neighboring gene AT-rich interaction domain 5A Neighboring gene microRNA 6898 Neighboring gene fer-1 like family member 5 Neighboring gene lectin, mannose-binding 2-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:36501343-36501452 Neighboring gene STARR-positive B cell enhancer ABC_E5746 Neighboring gene predicted gene, 33401

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of KANSL3 leads to defective inner cell mass and early embryonic lethality. Chander A, et al. Mol Reprod Dev, 2024 May. PMID 38769918, Free PMC Article
    2. The NSL complex maintains nuclear architecture stability via lamin A/C acetylation. Karoutas A, et al. Nat Cell Biol, 2019 Oct. PMID 31576060
    3. Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature. Sheikh BN, et al. Nat Cell Biol, 2020 Jul. PMID 32541879
    4. MOF-associated complexes ensure stem cell identity and Xist repression. Chelmicki T, et al. Elife, 2014 May 19. PMID 24842875, Free PMC Article
    5. A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. Nakano Y, et al. PLoS Genet, 2012. PMID 23055939, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of NSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NSL complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NSL complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of NSL complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    KAT8 regulatory NSL complex subunit 3
    Names
    NSL complex protein NSL3
    non-specific lethal 3 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310513.1 → NP_001297442.1  KAT8 regulatory NSL complex subunit 3 isoform 1

      See identical proteins and their annotated locations for NP_001297442.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK030079, AK129329, BC132293
      Consensus CDS
      CCDS78561.1
      UniProtKB/Swiss-Prot
      A2RSY1, Q6ZPU0, Q8C0P9
      Related
      ENSMUSP00000140597.2, ENSMUST00000186470.2
      Conserved Domains (1) summary
      pfam12695
      Location:342 → 436
      Abhydrolase_5; Alpha/beta hydrolase family

    2. NM_172652.3 → NP_766240.1  KAT8 regulatory NSL complex subunit 3 isoform 2

      See identical proteins and their annotated locations for NP_766240.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC132456
      Consensus CDS
      CCDS14877.1
      UniProtKB/Swiss-Prot
      A2RSY1
      Related
      ENSMUSP00000010597.4, ENSMUST00000010597.10
      Conserved Domains (1) summary
      pfam12695
      Location:342 → 436
      Abhydrolase_5; Alpha/beta hydrolase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      36374811..36408276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320240.3 → XP_017175729.1  KAT8 regulatory NSL complex subunit 3 isoform X2

      Conserved Domains (1) summary
      pfam12695
      Location:243 → 337
      Abhydrolase_5; Alpha/beta hydrolase family

    2. XM_017320236.3 → XP_017175725.1  KAT8 regulatory NSL complex subunit 3 isoform X2

      Conserved Domains (1) summary
      pfam12695
      Location:243 → 337
      Abhydrolase_5; Alpha/beta hydrolase family

    3. XM_036164306.1 → XP_036020199.1  KAT8 regulatory NSL complex subunit 3 isoform X3

      Related
      ENSMUSP00000140547.2, ENSMUST00000185912.7

    4. XM_011238482.3 → XP_011236784.1  KAT8 regulatory NSL complex subunit 3 isoform X2

      Conserved Domains (1) summary
      pfam12695
      Location:243 → 337
      Abhydrolase_5; Alpha/beta hydrolase family

    5. XM_030253628.2 → XP_030109488.1  KAT8 regulatory NSL complex subunit 3 isoform X4

    6. XM_017320242.2 → XP_017175731.1  KAT8 regulatory NSL complex subunit 3 isoform X4

    7. XM_006495902.4 → XP_006495965.1  KAT8 regulatory NSL complex subunit 3 isoform X1

      Conserved Domains (1) summary
      pfam12695
      Location:342 → 436
      Abhydrolase_5; Alpha/beta hydrolase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2RSY1.1 GenPept UniProtKB/Swiss-Prot:A2RSY1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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