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    Prokr1 prokineticin receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 58182, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Prokr1provided by MGI
    Official Full Name
    prokineticin receptor 1provided by MGI
    Primary source
    MGI:MGI:1929676
    See related
    Ensembl:ENSMUSG00000049409 AllianceGenome:MGI:1929676
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pkr1; Gpr73; Pk-r1; EG-VEGFR1
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in several processes, including cellular response to hormone stimulus; circadian rhythm; and negative regulation of apoptotic process. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; eye; gut; metanephros; and reproductive system. Orthologous to human PROKR1 (prokineticin receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in genital fat pad adult (RPKM 3.3), liver E14.5 (RPKM 2.0) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prokr1 in Genome Data Viewer
    Location:
    6 D1; 6 38.28 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (87555568..87567741, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (87578586..87590762, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene bone morphogenetic protein 10 Neighboring gene Rho GTPase activating protein 25 Neighboring gene STARR-positive B cell enhancer ABC_E861 Neighboring gene STARR-positive B cell enhancer ABC_E4843 Neighboring gene STARR-positive B cell enhancer ABC_E3663 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:87492045-87492293 Neighboring gene STARR-seq mESC enhancer starr_16556 Neighboring gene STARR-positive B cell enhancer ABC_E680 Neighboring gene STARR-seq mESC enhancer starr_16558 Neighboring gene predicted gene, 34222 Neighboring gene STARR-seq mESC enhancer starr_16560 Neighboring gene predicted gene, 34312 Neighboring gene STARR-seq mESC enhancer starr_16563 Neighboring gene aprataxin and PNKP like factor Neighboring gene predicted gene, 46964

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PROKR1-CREB-NR4A2 axis for oxidative muscle fiber specification and improvement of metabolic function. Mok J, et al. Proc Natl Acad Sci U S A, 2024 Jan 23. PMID 38232288, Free PMC Article
    2. Bv8, the amphibian homologue of the mammalian prokineticins, induces a proinflammatory phenotype of mouse macrophages. Martucci C, et al. Br J Pharmacol, 2006 Jan. PMID 16299550, Free PMC Article
    3. PROKR1 delivery by cell-derived vesicles restores the myogenic potential of Prokr1-deficient C2C12 myoblasts. Zhang C, et al. Nanomedicine, 2021 Oct. PMID 34314870
    4. Impaired nociception and inflammatory pain sensation in mice lacking the prokineticin receptor PKR1: focus on interaction between PKR1 and the capsaicin receptor TRPV1 in pain behavior. Negri L, et al. J Neurosci, 2006 Jun 21. PMID 16793879, Free PMC Article
    5. Genetic inactivation of prokineticin receptor-1 leads to heart and kidney disorders. Boulberdaa M, et al. Arterioscler Thromb Vasc Biol, 2011 Apr. PMID 21273561

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PROKR1 delivery by cell-derived vesicles restores the myogenic potential of Prokr1-deficient C2C12 myoblasts.
      Title: PROKR1 delivery by cell-derived vesicles restores the myogenic potential of Prokr1-deficient C2C12 myoblasts.
    2. Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to beta-arrestin 2.
      Title: Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to β-arrestin 2.
    3. Prokineticin receptor 1 ameliorates insulin resistance in skeletal muscle.
      Title: Prokineticin receptor 1 ameliorates insulin resistance in skeletal muscle.
    4. Upon high fat diet exposure, PKR1 (tcf-/-) mice displayed excessive fat deposition in the atrioventricular groove, perivascular area, and pericardium, which was accompanied by an impaired vascular network and cardiac dysfunction.
      Title: Prokineticin receptor-1-dependent paracrine and autocrine pathways control cardiac tcf21(+) fibroblast progenitor cell transformation into adipocytes and vascular cells.
    5. The study shows that PK2beta ligand, a splice variant of prokineticin 2, is able to modulate and drive signaling through prokineticin receptor 1.
      Title: PK2β ligand, a splice variant of prokineticin 2, is able to modulate and drive signaling through PKR1 receptor.
    6. The authors discovered that PKR1 regulates epicardial-mesenchymal transition (EMT) for epicardial-derived progenitor cell (EPDC), formation. This event affects at least three consequential steps during heart development: (i) EPDC and cardiomyocyte proliferation involved in thickening of an outer compact ventricular chamber wall, (ii) rhythmicity, (iii) formation of coronary circulation.
      Title: Prokineticin receptor-1 signaling promotes Epicardial to Mesenchymal Transition during heart development.
    7. These results establish PKR1 via NFATc3 as a crucial modifier of mesenchymal-epithelial transition processing to the development of nephron.
      Title: Prokineticin receptor 1 is required for mesenchymal-epithelial transition in kidney development.
    8. show that MRAP2 significantly and specifically inhibits PKR1 signaling.
      Title: The Melanocortin Receptor Accessory Protein 2 promotes food intake through inhibition of the Prokineticin Receptor-1.
    9. Data show that the prokineticins and their receptors PROK2, PKR1 and PKR2 contributes to altered sensitivity in diabetic neuropathy and its inhibition blocked both allodynia and inflammatory events underlying disease.
      Title: Antagonism of the Prokineticin System Prevents and Reverses Allodynia and Inflammation in a Mouse Model of Diabetes.
    10. These results suggest PKR1 to be a crucial player in the preadipocyte proliferation and differentiation.
      Title: Prokineticin receptor 1 as a novel suppressor of preadipocyte proliferation and differentiation to control obesity.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables neuropeptide Y receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in circadian rhythm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within circadian rhythm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in coronary vasculature development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    prokineticin receptor 1
    Names
    G-protein coupled receptor 73

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355655.1 → NP_001342584.1  prokineticin receptor 1

      Status: VALIDATED

      Source sequence(s)
      AC125171
      Consensus CDS
      CCDS20323.1
      UniProtKB/Swiss-Prot
      Q3U0M4, Q6PD11, Q9JKL1
      Related
      ENSMUSP00000144999.2, ENSMUST00000204682.3
      Conserved Domains (1) summary
      cd15204
      Location:63 → 353
      7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_021381.4 → NP_067356.2  prokineticin receptor 1

      See identical proteins and their annotated locations for NP_067356.2

      Status: VALIDATED

      Source sequence(s)
      AC125171, BC059003
      Consensus CDS
      CCDS20323.1
      UniProtKB/Swiss-Prot
      Q3U0M4, Q6PD11, Q9JKL1
      Related
      ENSMUSP00000059034.8, ENSMUST00000050887.9
      Conserved Domains (1) summary
      cd15204
      Location:63 → 353
      7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      87555568..87567741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506433.5 → XP_006506496.1  prokineticin receptor 1 isoform X2

      Conserved Domains (2) summary
      cd14964
      Location:18 → 48
      7tm_GPCRs; TM helix 3 [structural motif]
      cl28897
      Location:1 → 234
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_006506432.5 → XP_006506495.1  prokineticin receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006506495.1

      UniProtKB/Swiss-Prot
      Q3U0M4, Q6PD11, Q9JKL1
      Conserved Domains (1) summary
      cd15204
      Location:63 → 353
      7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JKL1.2 GenPept UniProtKB/Swiss-Prot:Q9JKL1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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