Sla src-like adaptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slaprovided by MGI
Official Full Name: src-like adaptorprovided by MGI
Primary source: MGI:MGI:104295
See related: Ensembl:ENSMUSG00000022372 AllianceGenome:MGI:104295
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Slap; Slap-1
Summary: Predicted to enable epidermal growth factor receptor binding activity and phosphotyrosine residue binding activity. Predicted to be involved in regulation of MAPK cascade and signal transduction. Predicted to be located in endosome. Predicted to be part of COP9 signalosome. Predicted to be active in cytoplasm; nucleoplasm; and plasma membrane. Is expressed in several structures, including alimentary system; brain; eye; hemolymphoid system; and musculoskeletal system. Orthologous to human SLA (Src like adaptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in thymus adult (RPKM 31.9), spleen adult (RPKM 9.7) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D2; 15 29.3 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (66652713..66703921, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (66780819..66831829, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SLAP Is a Negative Regulator of FcepsilonRI Receptor-Mediated Signaling and Allergic Response.
Title: SLAP Is a Negative Regulator of FcεRI Receptor-Mediated Signaling and Allergic Response.
SLAP and SLAP2 are critical inhibitors of platelet (hem)ITAM signaling in the setting of arterial thrombosis and ischemic stroke
Title: SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice.
SLAP is a critical regulator of B-cell development and function and its deficiency leads to decreased autoreactive B cells that are otherwise maintained by inefficient receptor editing or failed negative selection.
Title: SLAP deficiency decreases dsDNA autoantibody production.
Src-like adaptor protein (SLAP) functions as a negative regulator of the granulocyte-macrophage colony-stimulating factor receptor (GM-CSFR) generation of monocyte-derived dendritic cells of bone marrow origin.
Title: The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation.
SLAP deficiency dramatically reduces both the incidence and severity of arthritis and prevents development of chronic arthritis in the double SKG (mutant ZAP70) Src-like adapter protein (SLAP) knockout mouse model.
Title: SLAP deficiency enhances number and function of regulatory T cells preventing chronic autoimmune arthritis in SKG mice.
SLAP negatively regulates differentiation of osteoclasts and proliferation of their precursors.
Title: Src-like adaptor protein regulates osteoclast generation and survival.
SLAP has a conserved function in B and T cells by adapting c-Cbl to the antigen-receptor complex and targeting it for degradation
Title: Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner.
SLAP functions in a pathway that requires the phosphorylated TCRzeta chain and the Src family kinase Lck, but not ZAP-70 (zeta-associated protein of 70 kD).
Title: Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sla (e-PCR), detects polymorphism
- UniSTS:144406

D11S3038 (e-PCR)
- UniSTS:152140

Sla (e-PCR), detects polymorphism
- UniSTS:507225

Sla (e-PCR), detects polymorphism
- UniSTS:499140

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables epidermal growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphotyrosine residue binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: src-like-adapter

Names: src-like-adapter protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001029841.5 → NP_001025012.1 src-like-adapter isoform a

See identical proteins and their annotated locations for NP_001025012.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AC107859, AC157560

Consensus CDS

CCDS49622.1

UniProtKB/TrEMBL

A0A0R4J247

Related

ENSMUSP00000131865.2, ENSMUST00000168522.2

Conserved Domains (2) summary

cd10344
Location:89 → 186

SH2_SLAP; Src homology 2 domain found in Src-like adaptor proteins

cd12010
Location:42 → 96

SH3_SLAP; Src homology 3 domain of Src-Like Adaptor Protein
NM_001411767.1 → NP_001398696.1 src-like-adapter isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, skips a coding exon, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.

Source sequence(s)

AC107859, AC157560
NM_009192.4 → NP_033218.1 src-like-adapter isoform b

See identical proteins and their annotated locations for NP_033218.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.

Source sequence(s)

AC107859, AC157560

Consensus CDS

CCDS27509.1

UniProtKB/Swiss-Prot

Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8

UniProtKB/TrEMBL

Q4FJX0

Related

ENSMUSP00000127901.2, ENSMUST00000164163.8

Conserved Domains (2) summary

cd10344
Location:73 → 170

SH2_SLAP; Src homology 2 domain found in Src-like adaptor proteins

cd12010
Location:26 → 80

SH3_SLAP; Src homology 3 domain of Src-Like Adaptor Protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

66652713..66703921 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159288.1 → XP_036015181.1 src-like-adapter isoform X2

UniProtKB/Swiss-Prot

Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8

UniProtKB/TrEMBL

Q4FJX0

Conserved Domains (2) summary

cd10344
Location:73 → 170

SH2_SLAP; Src homology 2 domain found in Src-like adaptor proteins

cd12010
Location:26 → 80

SH3_SLAP; Src homology 3 domain of Src-Like Adaptor Protein
XM_030248433.2 → XP_030104293.1 src-like-adapter isoform X2

UniProtKB/Swiss-Prot

Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8

UniProtKB/TrEMBL

Q4FJX0

Conserved Domains (2) summary

cd10344
Location:73 → 170

SH2_SLAP; Src homology 2 domain found in Src-like adaptor proteins

cd12010
Location:26 → 80

SH3_SLAP; Src homology 3 domain of Src-Like Adaptor Protein
XM_017316522.3 → XP_017172011.1 src-like-adapter isoform X1

Related

ENSMUSP00000130222.2, ENSMUST00000168589.8

Conserved Domains (2) summary

cd10344
Location:112 → 209

SH2_SLAP; Src homology 2 domain found in Src-like adaptor proteins

cd12010
Location:65 → 119

SH3_SLAP; Src homology 3 domain of Src-Like Adaptor Protein