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    Phlda1 pleckstrin homology like domain, family A, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 21664, updated on 9-Dec-2024

    Summary

    Official Symbol
    Phlda1provided by MGI
    Official Full Name
    pleckstrin homology like domain, family A, member 1provided by MGI
    Primary source
    MGI:MGI:1096880
    See related
    Ensembl:ENSMUSG00000020205 AllianceGenome:MGI:1096880
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tdag; TDAG51; DT1P1B11
    Summary
    Predicted to enable phosphatidylinositol phosphate binding activity. Acts upstream of or within FasL biosynthetic process. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; limb segment; respiratory system; and sensory organ. Orthologous to human PHLDA1 (pleckstrin homology like domain family A member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal adult (RPKM 67.6), stomach adult (RPKM 50.4) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Phlda1 in Genome Data Viewer
    Location:
    10 D1; 10 58.7 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (111342147..111344510)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (111506286..111508649)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene nucleosome assembly protein 1-like 1 Neighboring gene predicted gene, 25117 Neighboring gene STARR-positive B cell enhancer ABC_E6922 Neighboring gene high mobility group box 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:110947179-110947288 Neighboring gene predicted gene, 53630 Neighboring gene predicted gene, 30193

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytoplasmic vesicle  
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  

    General protein information

    Preferred Names
    pleckstrin homology-like domain family A member 1
    Names
    PQ-rich protein
    PQR protein
    T-cell death associated
    T-cell death-associated gene 51 protein
    proline- and glutamine-rich protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009344.3NP_033370.2  pleckstrin homology-like domain family A member 1

      See identical proteins and their annotated locations for NP_033370.2

      Status: VALIDATED

      Source sequence(s)
      BY378082, U44088
      Consensus CDS
      CCDS24167.2
      UniProtKB/Swiss-Prot
      Q3TY48, Q3UG87, Q62392
      Related
      ENSMUSP00000132815.2, ENSMUST00000164773.2
      Conserved Domains (2) summary
      smart00233
      Location:154261
      PH; Pleckstrin homology domain
      pfam12286
      Location:250274
      DUF3622; Protein of unknown function (DUF3622)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      111342147..111344510
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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