Uhrf2 ubiquitin-like, containing PHD and RING finger domains 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Uhrf2provided by MGI
Official Full Name: ubiquitin-like, containing PHD and RING finger domains 2provided by MGI
Primary source: MGI:MGI:1923718
See related: Ensembl:ENSMUSG00000024817 AllianceGenome:MGI:1923718
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nirf; 2310065A22Rik; D130071B19Rik
Summary: Enables histone binding activity. Predicted to be involved in several processes, including negative regulation of gene expression via chromosomal CpG island methylation; protein autoubiquitination; and regulation of cell cycle. Located in heterochromatin and nucleus. Is expressed in several structures, including central nervous system; ear; early conceptus; female reproductive system; and urinary system. Orthologous to human UHRF2 (ubiquitin like with PHD and ring finger domains 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 25.9), CNS E14 (RPKM 21.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C1; 19 24.73 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (30007920..30071126)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (30030430..30093726)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

E3 Ubiquitin Ligase Uhrf2 Knockout Reveals a Critical Role in Social Behavior and Synaptic Plasticity in the Hippocampus.
Title: E3 Ubiquitin Ligase Uhrf2 Knockout Reveals a Critical Role in Social Behavior and Synaptic Plasticity in the Hippocampus.
The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.
Title: The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.
UHRF2 regulates cell cycle, epigenetics and gene expression to control the timing of retinal progenitor and ganglion cell differentiation.
Title: UHRF2 regulates cell cycle, epigenetics and gene expression to control the timing of retinal progenitor and ganglion cell differentiation.
During limb development in mouse embryos, Uhrf2 is expressed in the undifferentiated autopodial mesoderm and in subsequent stages, expression becomes restricted to the interdigital mesoderm. By day 14 post coitum, interdigit regression is almost accomplished and Uhrf gene expression become restricted to zones of the joint formation.
Title: UHRF genes regulate programmed interdigital tissue regression and chondrogenesis in the embryonic limb.
These results suggested that Uhrf2 deletion selectively blocked the development of the DG crest and impaired hippocampus-dependent learning and memory. Our study will facilitate a better understanding of the role of Uhrf2 protein in the central nervous system.
Title: Uhrf2 deletion impairs the formation of hippocampus-dependent memory by changing the structure of the dentate gyrus.
5mC levels are decreased at certain genomic loci in the brains of Uhrf2 knockout mice. UHRF KO mice develop frequent spontaneous seizures.
Title: UHRF2 regulates local 5-methylcytosine and suppresses spontaneous seizures.
Uhrf2 null mice exhibit a reduction of 5-Hydroxymethylcytosine in the brain, including the cortex and hippocampus. Furthermore, the Uhrf2 null mice exhibit a partial impairment in spatial memory acquisition and retention.
Title: The 5-Hydroxymethylcytosine (5hmC) Reader UHRF2 Is Required for Normal Levels of 5hmC in Mouse Adult Brain and Spatial Learning and Memory.
Uhrf2 is highly expressed in aorta and aortic vascular smooth muscle cells.
Title: Uhrf2 is important for DNA damage response in vascular smooth muscle cells.
UHRF2 is not able to rescue the DNA methylation defect in Uhrf1 null mouse embryonic stem cells.
Title: S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (1)
Targeted (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI426270 (e-PCR)
- UniSTS:160822

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables SUMO transferase activity	ISO Inferred from Sequence Orthology more info
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of gene expression via chromosomal CpG island methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in pericentric heterochromatin	IEA Inferred from Electronic Annotation more info
located_in pericentric heterochromatin	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase UHRF2

Names: Np95-like ring finger protein; RING-type E3 ubiquitin transferase UHRF2; nuclear protein 97; nuclear zinc finger protein Np97; ubiquitin-like PHD and RING finger domain-containing protein 2; ubiquitin-like-containing PHD and RING finger domains protein 2

NP_001406258.1

EC 2.3.2.27

NP_001406259.1

EC 2.3.2.27

NP_001406260.1

EC 2.3.2.27

NP_001406261.1

EC 2.3.2.27

NP_001406262.1

EC 2.3.2.27

NP_001406263.1

EC 2.3.2.27

NP_659122.2

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419329.1 → NP_001406258.1 E3 ubiquitin-protein ligase UHRF2 isoform 2

Status: VALIDATED

Source sequence(s)

AC111048, AC162613
NM_001419330.1 → NP_001406259.1 E3 ubiquitin-protein ligase UHRF2 isoform 3

Status: VALIDATED

Source sequence(s)

AC111048, AC162613
NM_001419331.1 → NP_001406260.1 E3 ubiquitin-protein ligase UHRF2 isoform 4

Status: VALIDATED

Source sequence(s)

AC111048, AC162613
NM_001419332.1 → NP_001406261.1 E3 ubiquitin-protein ligase UHRF2 isoform 5

Status: VALIDATED

Source sequence(s)

AC111048, AC162613
NM_001419333.1 → NP_001406262.1 E3 ubiquitin-protein ligase UHRF2 isoform 5

Status: VALIDATED

Source sequence(s)

AC111048, AC162613
NM_001419334.1 → NP_001406263.1 E3 ubiquitin-protein ligase UHRF2 isoform 6

Status: VALIDATED

Source sequence(s)

AC111048, AC162613
NM_144873.3 → NP_659122.2 E3 ubiquitin-protein ligase UHRF2 isoform 1

See identical proteins and their annotated locations for NP_659122.2

Status: VALIDATED

Source sequence(s)

AC111048, AC162613

Consensus CDS

CCDS37955.1

UniProtKB/Swiss-Prot

Q7TMI3, Q8BG56, Q8BJP6, Q8BY30, Q8K1I5

Related

ENSMUSP00000025739.8, ENSMUST00000025739.14

Conserved Domains (6) summary

cd01797
Location:1 → 76

NIRF_N; amino-terminal ubiquitin-like domain of Np95 and NIRF

smart00213
Location:3 → 74

UBQ; Ubiquitin homologues

cd00162
Location:733 → 776

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd15617
Location:347 → 393

PHD_UHRF2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)

pfam02182
Location:447 → 615

SAD_SRA; SAD/SRA domain

pfam12148
Location:126 → 313

TTD; Tandem tudor domain within UHRF1