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    Rem1 RRAD and GEM like GTPase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366232, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rem1provided by RGD
    Official Full Name
    RRAD and GEM like GTPase 1provided by RGD
    Primary source
    RGD:1306560
    See related
    EnsemblRapid:ENSRNOG00000007567 AllianceGenome:RGD:1306560
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTP binding activity; calcium channel regulator activity; and transmembrane transporter binding activity. Predicted to be involved in negative regulation of high voltage-gated calcium channel activity. Predicted to act upstream of or within negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel and regulation of skeletal muscle contraction by calcium ion signaling. Predicted to be located in I band and T-tubule. Predicted to be active in plasma membrane. Orthologous to human REM1 (RRAD and GEM like GTPase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 86.3), Kidney (RPKM 49.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rem1 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (161563984..161572478)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (141103722..141112206)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (148108500..148116992)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene defensin beta 36 Neighboring gene defensin beta 25 Neighboring gene uncharacterized LOC102553281 Neighboring gene histocompatibility minor 13 Neighboring gene MCTS family member 2 Neighboring gene uncharacterized LOC134486187 Neighboring gene inhibitor of DNA binding 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1. Jhun BS, et al. Circ Res, 2012 Jan 6. PMID 22076634, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114556

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of skeletal muscle contraction by calcium ion signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in I band ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GTP-binding protein REM 1
    Names
    RAS (RAD and GEM)-like GTP-binding 1
    rad and gem related GTP binding protein 1
    NP_001020924.1
    XP_006235340.1
    XP_038961535.1
    XP_038961536.1
    XP_063140361.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025753.2 → NP_001020924.1  GTP-binding protein REM 1

      See identical proteins and their annotated locations for NP_001020924.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6KHP5, F7EX35, Q4KLY1
      Conserved Domains (2) summary
      smart00010
      Location:81 → 245
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cd04148
      Location:81 → 297
      RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases

    2. NM_001434435.1 → NP_001421364.1  GTP-binding protein REM 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      161563984..161572478
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235278.5 → XP_006235340.1  GTP-binding protein REM 1 isoform X1

      UniProtKB/TrEMBL
      A6KHP5, F7EX35, Q4KLY1
      Related
      ENSRNOP00000010149.4, ENSRNOT00000010149.9
      Conserved Domains (2) summary
      smart00010
      Location:81 → 245
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cd04148
      Location:81 → 297
      RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases

    2. XM_039105607.2 → XP_038961535.1  GTP-binding protein REM 1 isoform X2

      Conserved Domains (1) summary
      cl38936
      Location:81 → 139
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_039105608.2 → XP_038961536.1  GTP-binding protein REM 1 isoform X3

      Conserved Domains (1) summary
      cl38936
      Location:81 → 139
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. XM_063284291.1 → XP_063140361.1  GTP-binding protein REM 1 isoform X1

      UniProtKB/TrEMBL
      A6KHP5, F7EX35, Q4KLY1
    Nucleotide Protein Strain
    Heading Accession and Version

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