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    Etaa1 ETAA1 activator of ATR kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498420, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Etaa1provided by RGD
    Official Full Name
    ETAA1 activator of ATR kinaseprovided by RGD
    Primary source
    RGD:1560957
    See related
    EnsemblRapid:ENSRNOG00000006185 AllianceGenome:RGD:1560957
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Etaa1l1; RGD1560957
    Summary
    Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including positive regulation of protein serine/threonine kinase activity; regulation of cell cycle phase transition; and replication fork processing. Predicted to be located in cytosol; nuclear replication fork; and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 115.6), Spleen (RPKM 98.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Etaa1 in Genome Data Viewer
    Location:
    14q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (96500899..96515617, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (92298461..92314044, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (97196079..97199067, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096676 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC120096677 Neighboring gene uncharacterized LOC120096678 Neighboring gene uncharacterized LOC134481793

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic G2/M transition checkpoint ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA damage checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear replication fork ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ewing's tumor-associated antigen 1
    Names
    Ewing tumor-associated antigen 1
    Ewing tumor-associated antigen 1-like 1
    ewing's tumor-associated antigen 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109094.2 → NP_001102564.1  ewing's tumor-associated antigen 1

      See identical proteins and their annotated locations for NP_001102564.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6AIP4, A6JQ01, D3ZQ67
      Related
      ENSRNOP00000008135.6, ENSRNOT00000008135.8
      Conserved Domains (1) summary
      pfam15350
      Location:76 → 859
      ETAA1; Ewing's tumour-associated antigen 1 homologue

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      96500899..96515617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273496.1 → XP_063129566.1  ewing's tumor-associated antigen 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AIP4

    2. XM_063273495.1 → XP_063129565.1  ewing's tumor-associated antigen 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AIP4

    3. XM_039092323.2 → XP_038948251.1  ewing's tumor-associated antigen 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AIP4
      Conserved Domains (1) summary
      pfam15350
      Location:1 → 709
      ETAA1; Ewing's tumor-associated antigen 1 homolog

    4. XM_039092321.2 → XP_038948249.1  ewing's tumor-associated antigen 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AIP4
      Conserved Domains (1) summary
      pfam15350
      Location:1 → 748
      ETAA1; Ewing's tumor-associated antigen 1 homolog

    5. XM_039092324.2 → XP_038948252.1  ewing's tumor-associated antigen 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AIP4
      Conserved Domains (1) summary
      pfam15350
      Location:1 → 669
      ETAA1; Ewing's tumor-associated antigen 1 homolog
    Nucleotide Protein Strain
    Heading Accession and Version

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