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    Hapstr1 HUWE1 associated protein modifying stress responses [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302913, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Hapstr1provided by RGD
    Official Full Name
    HUWE1 associated protein modifying stress responsesprovided by RGD
    Primary source
    RGD:1309748
    See related
    EnsemblRapid:ENSRNOG00000002545 AllianceGenome:RGD:1309748
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309748
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of signal transduction by p53 class mediator and regulation of cellular response to stress. Predicted to be located in cytoplasm and nucleus. Orthologous to human HAPSTR1 (HUWE1 associated protein modifying stress responses). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 261.8), Testes (RPKM 222.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hapstr1 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (7252737..7281678, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (6746037..6774992, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (6841071..6870011, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352212 Neighboring gene uncharacterized LOC103693272 Neighboring gene uncharacterized LOC102546403 Neighboring gene ubiquitin specific peptidase 7 Neighboring gene cytochrome c oxidase subunit 6B1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cellular response to stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    HUWE1-associated protein modifying stress responses 1
    Names
    UPF0472 protein C16orf72 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106972.1 → NP_001100442.1  HUWE1-associated protein modifying stress responses 1

      Status: PROVISIONAL

      Source sequence(s)
      CH474017
      UniProtKB/TrEMBL
      A6K4L5, D3ZK25
      Related
      ENSRNOP00000003439.4, ENSRNOT00000003439.6
      Conserved Domains (1) summary
      pfam15251
      Location:25 → 273
      DUF4588; Domain of unknown function (DUF4588)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      7252737..7281678 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245754.5 → XP_006245816.1  HUWE1-associated protein modifying stress responses 1 isoform X1

      UniProtKB/TrEMBL
      A6K4L5, D3ZK25
      Conserved Domains (1) summary
      pfam15251
      Location:25 → 273
      DUF4588; Domain of unknown function (DUF4588)
    Nucleotide Protein Strain
    Heading Accession and Version

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