Man1a1 mannosidase, alpha, class 1A, member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Man1a1provided by RGD
Official Full Name: mannosidase, alpha, class 1A, member 1provided by RGD
Primary source: RGD:1310891
See related: EnsemblRapid:ENSRNOG00000000800 AllianceGenome:RGD:1310891
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Man1a; Aa2-166
Summary: Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in mannose trimming involved in glycoprotein ERAD pathway and protein targeting to ER. Predicted to be located in several cellular components, including Golgi apparatus; cytosol; and endoplasmic reticulum-Golgi intermediate compartment. Predicted to be active in Golgi membrane and endoplasmic reticulum. Orthologous to human MAN1A1 (mannosidase alpha class 1A member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 548.2), Adrenal (RPKM 498.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (33745158..33928584, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (33202509..33385747, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (35257688..35450132, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of TOAG-1 and alpha-1,2-mannosidase expression occurred in graft infiltrating cells and expression of both genes was also downregulated after T-cell activation in vitro.
Title: Identification of gene markers for the prediction of allograft rejection or permanent acceptance.

Submit: New GeneRIF Correction

General gene information

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Markers

Man1a (e-PCR), detects polymorphism
- UniSTS:527408

UniSTS:498241 (e-PCR)
- UniSTS:498241

Man1a (e-PCR), detects polymorphism
- UniSTS:498241

Man1a (e-PCR), detects polymorphism
- UniSTS:499066

Man1a (e-PCR), detects polymorphism
- UniSTS:499067

D20Rat76 (e-PCR), detects polymorphism
- UniSTS:227307

BF387907 (e-PCR)
- UniSTS:244467

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in mannose trimming involved in glycoprotein ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to ER	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

Names: mannosidase 1, alpha; mannosyl-oligosaccharide alpha-1,2-mannosidase

NP_001028828.1

EC 3.2.1.113

XP_006256559.1

EC 3.2.1.113

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033656.1 → NP_001028828.1 mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

See identical proteins and their annotated locations for NP_001028828.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A0A0G2JW29, A6K4A2, G3V9N9

Related

ENSRNOP00000054231.1, ENSRNOT00000057422.4

Conserved Domains (1) summary

pfam01532
Location:204 → 642

Glyco_hydro_47; Glycosyl hydrolase family 47

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

33745158..33928584 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256497.3 → XP_006256559.1 mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X1

UniProtKB/TrEMBL

A0A0G2JW29, A0A8I5ZJA7

Related

ENSRNOP00000076820.1, ENSRNOT00000101500.2

Conserved Domains (1) summary

pfam01532
Location:295 → 733

Glyco_hydro_47; Glycosyl hydrolase family 47