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    Fam110a family with sequence similarity 110, member A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311535, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fam110aprovided by RGD
    Official Full Name
    family with sequence similarity 110, member Aprovided by RGD
    Primary source
    RGD:1308904
    See related
    EnsemblRapid:ENSRNOG00000050946 AllianceGenome:RGD:1308904
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308904
    Summary
    Predicted to be involved in mitotic spindle organization. Predicted to be located in several cellular components, including cell cortex; cytosol; and microtubule cytoskeleton. Orthologous to human FAM110A (family with sequence similarity 110 member A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 54.2), Thymus (RPKM 25.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fam110a in Genome Data Viewer
    Location:
    3q41
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (160934815..160945405, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (140474484..140485074, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (147476580..147487170, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101753 Neighboring gene angiopoietin 4 Neighboring gene uncharacterized LOC120101754 Neighboring gene ribosomal protein S29, pseudogene 15 Neighboring gene solute carrier family 52 member 3 Neighboring gene uncharacterized LOC120101756

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM110A
    Names
    serine threonine rich protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014050.2 → NP_001014072.2  protein FAM110A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' exon and has an upstream AUG start codon, compared to variant 1. The resulting isoform (2) is longer at the N-terminus, compared to isoform 1.
      Source sequence(s)
      BC079251, CB556608, CB766675
      UniProtKB/TrEMBL
      M0RB04, Q6AXZ9
      Related
      ENSRNOP00000066725.2, ENSRNOT00000074295.4
      Conserved Domains (2) summary
      pfam14160
      Location:213 → 318
      FAM110_C; Centrosome-associated C terminus
      pfam14161
      Location:34 → 134
      FAM110_N; Centrosome-associated N terminus

    2. NM_001244768.1 → NP_001231697.1  protein FAM110A isoform 1

      See identical proteins and their annotated locations for NP_001231697.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variants 2 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      CB556608, CB766675, CB806736, CV110036
      UniProtKB/TrEMBL
      A0A0G2JY94, G4XVC3, Q6AXZ9
      Related
      ENSRNOP00000072792.1, ENSRNOT00000077580.3
      Conserved Domains (2) summary
      pfam14160
      Location:183 → 288
      FAM110_C; Centrosome-associated C-terminus
      pfam14161
      Location:4 → 104
      FAM110_N; Centrosome-associated N-terminus

    3. NM_001244769.1 → NP_001231698.1  protein FAM110A isoform 1

      See identical proteins and their annotated locations for NP_001231698.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      CB556608, CB766675, CB806736, CV113127
      UniProtKB/TrEMBL
      A0A0G2JY94, G4XVC3, Q6AXZ9
      Related
      ENSRNOP00000070568.1, ENSRNOT00000084722.3
      Conserved Domains (2) summary
      pfam14160
      Location:183 → 288
      FAM110_C; Centrosome-associated C-terminus
      pfam14161
      Location:4 → 104
      FAM110_N; Centrosome-associated N-terminus

    4. NM_001244770.1 → NP_001231699.1  protein FAM110A isoform 1

      See identical proteins and their annotated locations for NP_001231699.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      BU670818, CB556608, CB766675, DY318143
      UniProtKB/TrEMBL
      A0A0G2JY94, G4XVC3, Q6AXZ9
      Related
      ENSRNOP00000107208.1, ENSRNOT00000141424.1
      Conserved Domains (2) summary
      pfam14160
      Location:183 → 288
      FAM110_C; Centrosome-associated C-terminus
      pfam14161
      Location:4 → 104
      FAM110_N; Centrosome-associated N-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      160934815..160945405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235231.5 → XP_006235293.1  protein FAM110A isoform X1

      UniProtKB/TrEMBL
      A0A8I6A2V0
      Related
      ENSRNOP00000083568.2, ENSRNOT00000116601.2
      Conserved Domains (2) summary
      pfam14160
      Location:345 → 450
      FAM110_C; Centrosome-associated C terminus
      pfam14161
      Location:166 → 266
      FAM110_N; Centrosome-associated N terminus

    2. XM_017591774.3 → XP_017447263.1  protein FAM110A isoform X2

      UniProtKB/TrEMBL
      A0A0G2JY94, G4XVC3, Q6AXZ9
      Conserved Domains (2) summary
      pfam14160
      Location:183 → 288
      FAM110_C; Centrosome-associated C-terminus
      pfam14161
      Location:4 → 104
      FAM110_N; Centrosome-associated N-terminus

    3. XM_039105051.2 → XP_038960979.1  protein FAM110A isoform X2

      UniProtKB/TrEMBL
      A0A0G2JY94, G4XVC3, Q6AXZ9
      Conserved Domains (2) summary
      pfam14160
      Location:183 → 288
      FAM110_C; Centrosome-associated C-terminus
      pfam14161
      Location:4 → 104
      FAM110_N; Centrosome-associated N-terminus

    4. XM_006235234.5 → XP_006235296.1  protein FAM110A isoform X2

      See identical proteins and their annotated locations for XP_006235296.1

      UniProtKB/TrEMBL
      A0A0G2JY94, G4XVC3, Q6AXZ9
      Related
      ENSRNOP00000087216.1, ENSRNOT00000093860.2
      Conserved Domains (2) summary
      pfam14160
      Location:183 → 288
      FAM110_C; Centrosome-associated C-terminus
      pfam14161
      Location:4 → 104
      FAM110_N; Centrosome-associated N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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