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    Chpf2 chondroitin polymerizing factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 100910, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Chpf2provided by MGI
    Official Full Name
    chondroitin polymerizing factor 2provided by MGI
    Primary source
    MGI:MGI:1917522
    See related
    Ensembl:ENSMUSG00000038181 AllianceGenome:MGI:1917522
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm42230; mir-671; mKIAA1402; 2010209O12Rik
    Summary
    Predicted to enable N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity and glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Predicted to be involved in chondroitin sulfate biosynthetic process. Is active in Golgi apparatus. Is expressed in articular cartilage; cartilage; and humerus. Orthologous to human CHPF2 (chondroitin polymerizing factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 27.5), ovary adult (RPKM 21.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Chpf2 in Genome Data Viewer
    Location:
    5; 5 A3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (24788950..24799396)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (24586744..24594398)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6314 Neighboring gene ATP-binding cassette, sub-family F member 2 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g pseudogene Neighboring gene SWI/SNF related BAF chromatin remodeling complex subunit D3 Neighboring gene microRNA 671 Neighboring gene glycerol-3-phosphate dehydrogenase 1-like pseudogene Neighboring gene STARR-seq mESC enhancer starr_12645 Neighboring gene STARR-positive B cell enhancer mm9_chr5:24180078-24180378 Neighboring gene STARR-positive B cell enhancer ABC_E1298 Neighboring gene STARR-positive B cell enhancer ABC_E11722 Neighboring gene negative regulator of ubiquitin-like proteins 1 Neighboring gene WD repeat domain 86

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family members. Izumikawa T, et al. J Biol Chem, 2008 Apr 25. PMID 18316376
    2. Biosynthesis of chondroitin sulphate by a Golgi-apparatus-enriched preparation from cultures of mouse mastocytoma cells. Silbert JE, et al. Biochem J, 1980 Aug 15. PMID 6781479, Free PMC Article
    3. Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage. Sakai K, et al. J Biol Chem, 2007 Feb 9. PMID 17145758
    4. Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2. Shimbo M, et al. PLoS One, 2017. PMID 29287114, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chondroitin sulfate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chondroitin sulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chondroitin sulfate glucuronyltransferase
    NP_598674.2
    XP_036020598.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133913.2 → NP_598674.2  chondroitin sulfate glucuronyltransferase precursor

      See identical proteins and their annotated locations for NP_598674.2

      Status: VALIDATED

      Source sequence(s)
      AK122504, BC036970
      Consensus CDS
      CCDS51436.1
      UniProtKB/TrEMBL
      Q3UU43, Q80TE1
      Related
      ENSMUSP00000112804.2, ENSMUST00000121863.5
      Conserved Domains (2) summary
      pfam05679
      Location:242 → 755
      CHGN; Chondroitin N-acetylgalactosaminyltransferase
      cl21608
      Location:177 → 269
      Galactosyl_T; Galactosyltransferase

    RNA

    1. NR_155297.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116136, AK138814, BE854619

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      24788950..24799396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164705.1 → XP_036020598.1  chondroitin sulfate glucuronyltransferase isoform X1

      UniProtKB/TrEMBL
      Q3UU43, Q80TE1
      Related
      ENSMUSP00000085633.5, ENSMUST00000088295.9
      Conserved Domains (2) summary
      pfam05679
      Location:242 → 755
      CHGN; Chondroitin N-acetylgalactosaminyltransferase
      cl21608
      Location:177 → 269
      Galactosyl_T; Galactosyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version

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