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    Lpar4 lysophosphatidic acid receptor 4 [ Mus musculus (house mouse) ]

    Gene ID: 78134, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lpar4provided by MGI
    Official Full Name
    lysophosphatidic acid receptor 4provided by MGI
    Primary source
    MGI:MGI:1925384
    See related
    Ensembl:ENSMUSG00000049929 AllianceGenome:MGI:1925384
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LPA4; p2y9; Gpr23; 5730485F04Rik
    Summary
    Enables lysophosphatidic acid binding activity and lysophosphatidic acid receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in several structures, including branchial arch; cardiovascular system; future brain; limb; and sensory organ. Orthologous to human LPAR4 (lysophosphatidic acid receptor 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 7.9), CNS E11.5 (RPKM 2.4) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lpar4 in Genome Data Viewer
    Location:
    X D; X 47.39 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (105964231..105977505)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (106920625..106933899)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene retrotransposon Gag like 3 Neighboring gene STARR-seq mESC enhancer starr_47740 Neighboring gene purinergic receptor P2Y, G-protein coupled 10 Neighboring gene STARR-positive B cell enhancer ABC_E11054 Neighboring gene STARR-positive B cell enhancer ABC_E11686 Neighboring gene purinergic receptor P2Y, G-protein coupled 10B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Role of LPA4/p2y9/GPR23 in negative regulation of cell motility. Lee Z, et al. Mol Biol Cell, 2008 Dec. PMID 18843048, Free PMC Article
    2. The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells. Igarashi H, et al. Sci Rep, 2015 Jun 19. PMID 26090649, Free PMC Article
    3. LPA receptor 4 deficiency attenuates experimental atherosclerosis. Yang L, et al. J Lipid Res, 2019 May. PMID 30796085, Free PMC Article
    4. LPA4-Mediated Vascular Network Formation Increases the Efficacy of Anti-PD-1 Therapy against Brain Tumors. Eino D, et al. Cancer Res, 2018 Dec 1. PMID 30301839
    5. LPA(4)/GPR23 is a lysophosphatidic acid (LPA) receptor utilizing G(s)-, G(q)/G(i)-mediated calcium signaling and G(12/13)-mediated Rho activation. Lee CW, et al. J Biol Chem, 2007 Feb 16. PMID 17166850

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The LPAR4 may regulate the recruitment of specific sets of macrophages or their phenotypic switching in a manner that could influence the development of atherosclerosis.
      Title: LPA receptor 4 deficiency attenuates experimental atherosclerosis.
    2. the Galpha12/Galpha13-coupled receptors LPA4 and LPA6 synergistically regulate endothelial Dll4 expression through YAP/TAZ activation
      Title: Lysophosphatidic acid-induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4.
    3. activation of LPA4 is a promising approach for vascular regulation.
      Title: Lysophosphatidic Acid Receptor 4 Activation Augments Drug Delivery in Tumors by Tightening Endothelial Cell-Cell Contact.
    4. LPA4 plays a major role in the lymphocyte transmigration across high endothelial venules
      Title: Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes.
    5. The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells
      Title: The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells.
    6. These results suggest that LPA(4) regulates establishment of the structure and function of blood and lymphatic vessels during mouse embryogenesis
      Title: LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis.
    7. These results provide genetic and biochemical evidence that LPA(4) is a suppressor of LPA-dependent cell migration and invasion in contrast to the motility-stimulating Edg LPA receptors.
      Title: Role of LPA4/p2y9/GPR23 in negative regulation of cell motility.
    8. a direct role for LPA receptor signaling in cell transformation and tumorigenesis in conjunction with c-Myc
      Title: In vitro genetic screen identifies a cooperative role for LPA signaling and c-Myc in cell transformation.
    9. Affymetrix expression profiling shows that the C terminus of Runx2 regulates genes involved in G protein-coupled receptor signaling Rgs2, Rgs4, Rgs5, Rgs16, Gpr23, Gpr30, Gpr54, Gpr64, and Gna13.
      Title: Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lysophosphatidic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lysophosphatidic acid receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysophosphatidic acid receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    lysophosphatidic acid receptor 4
    Names
    G protein-coupled receptor 23
    LPA receptor 4
    LPA-4
    P2Y purinoceptor 9
    purinergic receptor 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175271.4 → NP_780480.2  lysophosphatidic acid receptor 4

      See identical proteins and their annotated locations for NP_780480.2

      Status: VALIDATED

      Source sequence(s)
      AL670943, BB619126, BC138893
      Consensus CDS
      CCDS30345.1
      UniProtKB/Swiss-Prot
      A2ADM5, Q8BKK1, Q8BLG2, Q8VE54
      Related
      ENSMUSP00000053986.8, ENSMUST00000060576.8
      Conserved Domains (1) summary
      cd15155
      Location:40 → 322
      7tmA_LPAR4; lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      105964231..105977505
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BLG2.2 GenPept UniProtKB/Swiss-Prot:Q8BLG2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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