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    Uaca uveal autoantigen with coiled-coil domains and ankyrin repeats [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315732, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Uacaprovided by RGD
    Official Full Name
    uveal autoantigen with coiled-coil domains and ankyrin repeatsprovided by RGD
    Primary source
    RGD:1560011
    See related
    EnsemblRapid:ENSRNOG00000012868 AllianceGenome:RGD:1560011
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560011
    Summary
    Predicted to enable transcription regulator inhibitor activity. Predicted to be involved in intrinsic apoptotic signaling pathway; negative regulation of inflammatory response; and negative regulation of intracellular signal transduction. Predicted to act upstream of or within several processes, including positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of protein import into nucleus; and response to UV. Predicted to be located in membrane; nucleus; and perinuclear region of cytoplasm. Predicted to be part of apoptosome. Predicted to be active in cytosol and nucleus. Orthologous to human UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 359.4), Heart (RPKM 182.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Uaca in Genome Data Viewer
    Location:
    8q24
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (70155059..70243416)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (61259415..61347789)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (65686586..65774940)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480063 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene hypothetical protein LOC691000 Neighboring gene uncharacterized LOC102551127

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel, embryonal carcinoma cell-associated molecule, nucling, that is up-regulated during cardiac muscle differentiation. Sakai T, et al. J Biochem, 2003 Apr. PMID 12761289
    2. Nucling mediates apoptosis by inhibiting expression of galectin-3 through interference with nuclear factor kappaB signalling. Liu L, et al. Biochem J, 2004 May 15. PMID 14961764, Free PMC Article
    3. Nucling recruits Apaf-1/pro-caspase-9 complex for the induction of stress-induced apoptosis. Sakai T, et al. J Biol Chem, 2004 Sep 24. PMID 15271982
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription regulator inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of apoptosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    uveal autoantigen with coiled-coil domains and ankyrin repeats

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195564.1 → NP_001182493.1  uveal autoantigen with coiled-coil domains and ankyrin repeats

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6GKP6, D3ZGS5
      Conserved Domains (4) summary
      pfam05483
      Location:534 → 1218
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      cd00204
      Location:99 → 222
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:107 → 199
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:136 → 166
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      70155059..70243416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243205.4 → XP_006243267.1  uveal autoantigen with coiled-coil domains and ankyrin repeats isoform X1

      See identical proteins and their annotated locations for XP_006243267.1

      UniProtKB/TrEMBL
      A0A8I6GKP6, A6J551
      Related
      ENSRNOP00000017233.7, ENSRNOT00000017233.9
      Conserved Domains (4) summary
      pfam05483
      Location:532 → 1216
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      cd00204
      Location:99 → 222
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:107 → 199
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:136 → 166
      ANK; ANK repeat [structural motif]

    2. XM_006243206.4 → XP_006243268.1  uveal autoantigen with coiled-coil domains and ankyrin repeats isoform X2

      UniProtKB/TrEMBL
      A0A0G2JT68, A0A8I6GKP6
      Related
      ENSRNOP00000110532.1, ENSRNOT00000140038.1
      Conserved Domains (4) summary
      pfam05483
      Location:517 → 1201
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      cd00204
      Location:84 → 207
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:92 → 184
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:121 → 151
      ANK; ANK repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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