GlcAT-I Glucuronyltransferase I [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: GlcAT-Iprovided by FlyBase
Official Full Name: Glucuronyltransferase Iprovided by FlyBase
Primary source: FLYBASE:FBgn0066114
Locus tag: Dmel_CG32775
See related: AllianceGenome:FB:FBgn0066114
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GH05057; CAA21824; CG32775; dGlcAT-I; DGlcAT-I; Dmel\CG32775; DmGlcAT-I; EG:EG0007.5; GH05057p; GlcAT1; RE38067
Summary: Enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity. Involved in proteoglycan biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Is expressed in several structures, including adult head; embryonic epipharynx; embryonic hypopharynx; epipharynx primordium; and gut section. Human ortholog(s) of this gene implicated in Barrett's esophagus; Larsen-like syndrome B3GAT3 type; and schizophrenia. Orthologous to several human genes including B3GAT3 (beta-1,3-glucuronyltransferase 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (4131211..4132833)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (4025244..4026866)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

novel glucuronyltransferases responsible for the synthesis of the conserved glycosaminoglycan-protein linkage region of proteoglycans
Title: Identification and characterization of three Drosophila melanogaster glucuronyltransferases responsible for the synthesis of the conserved glycosaminoglycan-protein linkage region of proteoglycans. Two novel homologs exhibit broad specificity toward oligosaccharides from proteoglycans, glycoproteins, and glycosphingolipids.

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chondroitin sulfate proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chondroitin sulfate proteoglycan biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in heparan sulfate proteoglycan biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteoglycan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

NP_726910.1

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain