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    Mtap Methylthioadenosine phosphorylase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36955, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Mtapprovided by FlyBase
    Official Full Name
    Methylthioadenosine phosphorylaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034215
    Locus tag
    Dmel_CG4802
    See related
    AllianceGenome:FB:FBgn0034215
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4802; Dmel\CG4802; MTAP
    Summary
    Predicted to enable S-methyl-5-thioadenosine phosphorylase activity. Predicted to be involved in L-methionine salvage from methylthioadenosine. Predicted to be active in cytosol. Is expressed in adult head; fat body primordium; and visceral trunk mesoderm. Human ortholog(s) of this gene implicated in biliary tract benign neoplasm and diaphyseal medullary stenosis with malignant fibrous histiocytoma. Orthologous to human MTAP (methylthioadenosine phosphorylase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mtap in Genome Data Viewer
    Location:
    54B7-54B7; 2-82 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17427795..17429315)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13315300..13316820)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene connector enhancer of ksr Neighboring gene lethal (2) k01209 Neighboring gene uncharacterized protein Neighboring gene Brahma associated protein 55kD Neighboring gene Lethal hybrid rescue Neighboring gene Egg-derived tyrosine phosphatase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Methylthioadenosine phosphorylase (MTAP) in hearing: gene disruption by chromosomal rearrangement in a hearing impaired individual and model organism analysis. Williamson RE, et al. Am J Med Genet A, 2007 Jul 15. PMID 17534888
    2. Unraveling the protective effect of a Drosophila phosphatidylethanolamine-binding protein upon bacterial infection by means of proteomics. Reumer A, et al. Dev Comp Immunol, 2009 Nov. PMID 19545586
    3. Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila. Parkhitko AA, et al. Genes Dev, 2016 Jun 15. PMID 27313316, Free PMC Article
    4. Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network. Orian A, et al. Genes Dev, 2003 May 1. PMID 12695332, Free PMC Article
    5. Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster. Dunn JG, et al. Elife, 2013 Dec 3. PMID 24302569, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables S-methyl-5-thioadenosine phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables S-methyl-5-thioadenosine phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-methionine salvage from methylthioadenosine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    methylthioadenosine phosphorylase
    Names
    CG4802-PA
    CG4802-PB
    CG4802-PC
    Mtap-PA
    Mtap-PB
    Mtap-PC
    methylthioadenosine phosphorylase ortholog
    NP_001261049.1
    NP_001286525.1
    NP_611208.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17427795..17429315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299596.1 → NP_001286525.1  methylthioadenosine phosphorylase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286525.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V813
      UniProtKB/TrEMBL
      A0A0B4LFH0
      Conserved Domains (2) summary
      COG0005
      Location:12 → 264
      XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
      cl00303
      Location:17 → 263
      PNP_UDP_1; Phosphorylase superfamily

    2. NM_137364.4 → NP_611208.1  methylthioadenosine phosphorylase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611208.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V813
      UniProtKB/TrEMBL
      A0A0B4LFH0
      Related
      FBpp0086072
      Conserved Domains (2) summary
      COG0005
      Location:12 → 264
      XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
      cl00303
      Location:17 → 263
      PNP_UDP_1; Phosphorylase superfamily

    3. NM_001274120.2 → NP_001261049.1  methylthioadenosine phosphorylase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261049.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG54
      Conserved Domains (2) summary
      COG0005
      Location:12 → 264
      XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
      cl00303
      Location:17 → 263
      PNP_UDP_1; Phosphorylase superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KG54 A0A0B4KG54
    A0A0B4LFH0 A0A0B4LFH0
    Q9V813.1 Q9V813

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