U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Edem1 ER degradation enhancer, mannosidase alpha-like 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31154, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Edem1provided by FlyBase
    Official Full Name
    ER degradation enhancer, mannosidase alpha-like 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0023511
    Locus tag
    Dmel_CG3810
    See related
    AllianceGenome:FB:FBgn0023511
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3810; dEDEM1; DM-pI; Dmel\CG3810; edem1; EDEM1; EG.86E4.2; EG:86E4.2
    Summary
    Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Involved in determination of adult lifespan; endoplasmic reticulum unfolded protein response; and ubiquitin-dependent glycoprotein ERAD pathway. Located in endoplasmic reticulum. Is expressed in gonad; imaginal disc; larval central nervous system; ring gland; and spermatozoon. Orthologous to human EDEM2 (ER degradation enhancing alpha-mannosidase like protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Edem1 in Genome Data Viewer
    Location:
    2B15-2B15; 1-0.2 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1903704..1908827, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1797737..1802860, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45929 Neighboring gene antisense RNA:CR43864 Neighboring gene Lipid droplet assembly factor 1 Neighboring gene uncharacterized protein Neighboring gene Myb-interacting protein 130 Neighboring gene Rabconnectin-3B Neighboring gene eukaryotic translation initiation factor 2B subunit epsilon

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Role of Drosophila EDEMs in the degradation of the alpha-1-antitrypsin Z variant. Jang BY, et al. Int J Mol Med, 2015 Apr. PMID 25716426, Free PMC Article
    2. The alpha-mannosidases: phylogeny and adaptive diversification. Gonzalez DS, et al. Mol Biol Evol, 2000 Feb. PMID 10677852
    3. Amyloid-β42 clearance and neuroprotection mediated by X-box binding protein 1 signaling decline with aging in the Drosophila brain. Marcora MS, et al. Neurobiol Aging, 2017 Dec. PMID 28917667
    4. Participation of dengue virus NS4B protein in the modulation of immune effectors dependent on ER stress in insect cells. Sepúlveda-Salinas KJ, et al. Cell Stress Chaperones, 2017 Nov. PMID 28755304, Free PMC Article
    5. Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans. Liu YL, et al. Aging Cell, 2009 Aug. PMID 19302370, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Edem1 activity in the fat body regulates insulin signalling and metabolic homeostasis in Drosophila.
      Title: Edem1 activity in the fat body regulates insulin signalling and metabolic homeostasis in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum mannose trimming IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum unfolded protein response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endoplasmic reticulum unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mannoprotein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mannose trimming involved in glycoprotein ERAD pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent glycoprotein ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent glycoprotein ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ER degradation enhancer, mannosidase alpha-like 1
    Names
    CG3810-PA
    CG3810-PB
    CG3810-PC
    CG3810-PD
    CG3810-PE
    Edem1-PA
    Edem1-PB
    Edem1-PC
    Edem1-PD
    Edem1-PE
    NP_001245483.1
    NP_001259152.1
    NP_569959.1
    NP_726777.1
    NP_726778.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1903704..1908827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166915.2 → NP_726778.1  ER degradation enhancer, mannosidase alpha-like 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726778.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46091, Q7JUF8
      Related
      FBpp0070337
      Conserved Domains (1) summary
      pfam01532
      Location:48 → 486
      Glyco_hydro_47; Glycosyl hydrolase family 47

    2. NM_001272223.2 → NP_001259152.1  ER degradation enhancer, mannosidase alpha-like 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259152.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PG98, O46091
      Conserved Domains (1) summary
      pfam01532
      Location:48 → 486
      Glyco_hydro_47; Glycosyl hydrolase family 47

    3. NM_001258554.2 → NP_001245483.1  ER degradation enhancer, mannosidase alpha-like 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245483.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46091, Q7JUF8
      Conserved Domains (1) summary
      pfam01532
      Location:48 → 486
      Glyco_hydro_47; Glycosyl hydrolase family 47

    4. NM_130603.3 → NP_569959.1  ER degradation enhancer, mannosidase alpha-like 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569959.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46091, Q7JUF8
      Related
      FBpp0070338
      Conserved Domains (1) summary
      pfam01532
      Location:48 → 486
      Glyco_hydro_47; Glycosyl hydrolase family 47

    5. NM_166914.2 → NP_726777.1  ER degradation enhancer, mannosidase alpha-like 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726777.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46091, Q7JUF8
      Related
      FBpp0070339
      Conserved Domains (1) summary
      pfam01532
      Location:48 → 486
      Glyco_hydro_47; Glycosyl hydrolase family 47
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PG98 M9PG98
    O46091 O46091
    Q7JUF8 Q7JUF8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools