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    CG18754 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 59145, updated on 9-Dec-2024

    Summary

    Official Symbol
    CG18754provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0042106
    Locus tag
    Dmel_CG18754
    See related
    AllianceGenome:FB:FBgn0042106
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cSP61; Dmel\CG18754; SP61
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in innate immune response and proteolysis. Predicted to be active in extracellular space. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; posterior endoderm; somatic muscle primordium; and trunk mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See CG18754 in Genome Data Viewer
    Location:
    95A7-95A7; 3-80 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23684057..23686537)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19509779..19512259)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3 subunit d1 Neighboring gene uncharacterized protein Neighboring gene Spatzle-Processing Enzyme Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43903 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    mobile_element

    • Loc: 23684752-23685179 mobile_element_type = transposon:roo{}1410

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    uncharacterized protein
    Names
    CG18754-PB
    CG18754-PC
    NP_001262877.1
    NP_652652.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23684057..23686537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_144395.5NP_652652.3  uncharacterized protein Dmel_CG18754, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652652.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9I7I1
      Conserved Domains (3) summary
      smart00020
      Location:108335
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:108338
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam12032
      Location:3584
      CLIP; Regulatory CLIP domain of proteinases
    2. NM_001275948.1NP_001262877.1  uncharacterized protein Dmel_CG18754, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262877.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHA5
      Conserved Domains (2) summary
      smart00020
      Location:63290
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:63293
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...