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    Apl Apollo [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 59216, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Aplprovided by FlyBase
    Official Full Name
    Apolloprovided by FlyBase
    Primary source
    FLYBASE:FBgn0042178
    Locus tag
    Dmel_CG32165
    See related
    AllianceGenome:FB:FBgn0042178
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-73Bb; CG18218; CG18861; CG32165; Dmel\CG32165; Imp4/5
    Summary
    Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to be active in cytoplasm and nucleus. Is expressed in organism and testis. Orthologous to human IPO4 (importin 4). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See Apl in Genome Data Viewer
    Location:
    73A11-73B1; 3-44 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16595181..16600459)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16588281..16593559)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene lethal (3) 73Ah Neighboring gene transformer Neighboring gene spindle defective 2 Neighboring gene pseudo Neighboring gene Artemis Neighboring gene uncharacterized protein Neighboring gene Proteasome beta6 subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sexual conflict drive in the rapid evolution of new gametogenesis genes. VanKuren NW, et al. Semin Cell Dev Biol, 2024 Jun-Jul. PMID 38309142
    2. Gene duplicates resolving sexual conflict rapidly evolved essential gametogenesis functions. VanKuren NW, et al. Nat Ecol Evol, 2018 Apr. PMID 29459709, Free PMC Article
    3. APOLLO, a testis-specific Drosophila ortholog of importin-4, mediates the loading of protamine-like protein Mst77F into sperm chromatin. Emelyanov AV, et al. J Biol Chem, 2023 Oct. PMID 37660905, Free PMC Article
    4. Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects. Mirsalehi A, et al. BMC Genomics, 2021 Dec 5. PMID 34863092, Free PMC Article
    5. Genomic analyses of new genes and their phenotypic effects reveal rapid evolution of essential functions in Drosophila development. Xia S, et al. PLoS Genet, 2021 Jul. PMID 34242211, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    apollo
    Names
    Apl-PA
    Apl-PB
    Apl-PC
    CG32165-PA
    CG32165-PB
    CG32165-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16595181..16600459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300155.1 → NP_001287084.1  apollo, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287084.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFW8, Q8SWQ9
      Conserved Domains (2) summary
      smart00913
      Location:29 → 90
      IBN_N; Importin-beta N-terminal domain
      sd00044
      Location:335 → 363
      HEAT; HEAT repeat [structural motif]

    2. NM_168676.2 → NP_730182.1  apollo, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730182.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SWQ9, Q9I7R5
      Related
      FBpp0075072
      Conserved Domains (2) summary
      smart00913
      Location:29 → 90
      IBN_N; Importin-beta N-terminal domain
      sd00044
      Location:356 → 384
      HEAT; HEAT repeat [structural motif]

    3. NM_001275027.1 → NP_001261956.1  apollo, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261956.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFW8, Q8SWQ9
      Conserved Domains (2) summary
      smart00913
      Location:29 → 90
      IBN_N; Importin-beta N-terminal domain
      sd00044
      Location:335 → 363
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFW8 M9PFW8
    Q9I7R5 Q9I7R5

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