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    Rab3 Rab3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36127, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Rab3provided by FlyBase
    Official Full Name
    Rab3provided by FlyBase
    Primary source
    FLYBASE:FBgn0005586
    Locus tag
    Dmel_CG7576
    See related
    AllianceGenome:FB:FBgn0005586
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAF58762; CG7576; dm-Rab3; Dmel\CG7576; DmRab3; drab3; dRab3; Drab3; DRab3; DRAB3; P25228; rab3; Rab3A
    Summary
    Enables GTP binding activity and magnesium ion binding activity. Involved in several processes, including cytoskeletal matrix organization at active zone; maintenance of presynaptic active zone structure; and regulation of neurotransmitter secretion. Located in presynaptic active zone. Colocalizes with synaptic vesicle. Is expressed in several structures, including brain; imaginal disc; mushroom body; sensory nervous system primordium; and synaptic neuropil domain. Orthologous to several human genes including RAB3A (RAB3A, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Rab3 in Genome Data Viewer
    Location:
    47B7-47B7; 2-63 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10721335..10729203, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6608840..6616708, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46229 Neighboring gene starry night Neighboring gene Carbonic anhydrase 13 Neighboring gene D-amino acid oxidase 1 Neighboring gene uncharacterized protein Neighboring gene Menage a trois 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. rab3A attachment to the synaptic vesicle membrane mediated by a conserved polyisoprenylated carboxy-terminal sequence. Johnston PA, et al. Neuron, 1991 Jul. PMID 1648935
    2. Demonstration of a Simple Epitope Tag Multimerization Strategy for Enhancing the Sensitivity of Protein Detection Using Drosophila vAChT. Tison KV, et al. G3 (Bethesda), 2020 Feb 6. PMID 31767639, Free PMC Article
    3. Synaptic Vesicle Proteins and Active Zone Plasticity. Kittel RJ, et al. Front Synaptic Neurosci, 2016. PMID 27148040, Free PMC Article
    4. Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP. Lardong JA, et al. Acta Crystallogr F Struct Biol Commun, 2015 Jan 1. PMID 25615965, Free PMC Article
    5. Quantitative super-resolution imaging of Bruchpilot distinguishes active zone states. Ehmann N, et al. Nat Commun, 2014 Aug 18. PMID 25130366, Free PMC Article

    See all (143) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study demonstrated that the Rab3-GEF Controls Active Zone Development at the Drosophila Neuromuscular Junction.
      Title: Rab3-GEF Controls Active Zone Development at the Drosophila Neuromuscular Junction.
    2. Findings suggest that Rab3 controls the distribution of active zone components via a vesicle docking mechanism that is consistent with standard Rab protein function.
      Title: Mutational Analysis of Rab3 Function for Controlling Active Zone Protein Composition at the Drosophila Neuromuscular Junction.
    3. High-resolution crystal structures of Drosophila Rab2 and Rab3 in complex with GMPPNP and magnesium.
      Title: Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP.
    4. Rab3 regulates basal synaptic strength and short-term plasticity at the level of release probability at individual sites.
      Title: Optical quantal analysis of synaptic transmission in wild-type and rab3-mutant Drosophila motor axons.
    5. The data of this study defined roles for Rab3-GAP and Rab3 in synaptic homeostasis and uncover a mechanism, acting at a late stage of vesicle release, that opposes the progression of homeostatic plasticity.
      Title: Rab3-GAP controls the progression of synaptic homeostasis at a late stage of vesicle release.
    6. This study showed that the small GTPase Rab3 controls the protein composition and release probability of individual active zones at the Drosophila neuromuscular junction.
      Title: Rab3 dynamically controls protein composition at active zones.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables myosin V binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rab protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cytoskeletal matrix organization at active zone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of presynaptic active zone structure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neurotransmitter secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of short-term neuronal synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in symbiont entry into host cell HMP PubMed 
    involved_in vesicle-mediated transport IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse HDA PubMed 
    located_in synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in synaptic vesicle HDA PubMed 
    colocalizes_with synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Rab3
    Names
    CG7576-PA
    CG7576-PB
    Rab-protein 3
    Rab3-PA
    Rab3-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10721335..10729203 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078963.3 → NP_523687.1  Rab3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523687.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25228, Q9V5N9
      UniProtKB/TrEMBL
      A0A4P7VAW6
      Related
      FBpp0087352
      Conserved Domains (1) summary
      cd01865
      Location:21 → 185
      Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D

    2. NM_001370044.1 → NP_001356961.1  Rab3, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25228, Q9V5N9
      UniProtKB/TrEMBL
      A0A4P7VAW6
      Conserved Domains (1) summary
      cd01865
      Location:21 → 185
      Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A4P7VAW6 A0A4P7VAW6
    P25228.1 P25228

    Gene LinkOut

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