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    exsA exoenzyme S transcriptional regulator ExsA [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 879712, updated on 11-Sep-2024

    Summary

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    Gene symbol
    exsA
    Gene description
    exoenzyme S transcriptional regulator ExsA
    Locus tag
    PA1713
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (1857273..1858109)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene exoenzyme S synthesis protein ExsB Neighboring gene hypothetical protein Neighboring gene type III export apparatus protein Neighboring gene type III secretion outer membrane protein PscC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The small RNA PrrH aggravates Pseudomonas aeruginosa-induced acute lung injury by regulating the type III secretion system activator ExsA. Shi Q, et al. Microbiol Spectr, 2024 Mar 5. PMID 38289930, Free PMC Article
    2. Structural Analysis of the Regulatory Domain of ExsA, a Key Transcriptional Regulator of the Type Three Secretion System in Pseudomonas aeruginosa. Shrestha M, et al. PLoS One, 2015. PMID 26317977, Free PMC Article
    3. Cloning and sequence analysis of a trans-regulatory locus required for exoenzyme S synthesis in Pseudomonas aeruginosa. Frank DW, et al. J Bacteriol, 1991 Oct. PMID 1655713, Free PMC Article
    4. Analyses of the DNA-binding and transcriptional activation properties of ExsA, the transcriptional activator of the Pseudomonas aeruginosa exoenzyme S regulon. Hovey AK, et al. J Bacteriol, 1995 Aug. PMID 7635828, Free PMC Article
    5. Characterization of ExsA and of ExsA-dependent promoters required for expression of the Pseudomonas aeruginosa type III secretion system. Brutinel ED, et al. Mol Microbiol, 2008 May. PMID 18373522

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The small RNA PrrH aggravates Pseudomonas aeruginosa-induced acute lung injury by regulating the type III secretion system activator ExsA.
      Title: The small RNA PrrH aggravates Pseudomonas aeruginosa-induced acute lung injury by regulating the type III secretion system activator ExsA.
    2. study reports that Vfr directly controls exsA transcription, the master regulator of T3SS gene expression, from a newly identified promoter located immediately upstream of exsA
      Title: Vfr Directly Activates exsA Transcription To Regulate Expression of the Pseudomonas aeruginosa Type III Secretion System.
    3. The crystal structure suggests two models for the ExsA dimer. Both models confirmed the previously shown involvement of helix alpha-3 in ExsA dimerization but one also suggest a role for helix alpha-2.
      Title: Structural Analysis of the Regulatory Domain of ExsA, a Key Transcriptional Regulator of the Type Three Secretion System in Pseudomonas aeruginosa.
    4. ExsD trimerization prevents ExsD from inhibiting ExsA-dependent transcription.
      Title: Self-trimerization of ExsD limits inhibition of the Pseudomonas aeruginosa transcriptional activator ExsA in vitro.
    5. The combined data support a model in which two ExsA(His) molecules bind adjacent sites on the promoter to activate type III secretion system gene transcription.
      Title: Characterization of ExsA and of ExsA-dependent promoters required for expression of the Pseudomonas aeruginosa type III secretion system.
    6. characterized the self-association states of ExsC, ExsD, and ExsE and the binding interactions of ExsC with ExsE and ExsD
      Title: Biochemical characterization of a regulatory cascade controlling transcription of the Pseudomonas aeruginosa type III secretion system.
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    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    exoenzyme S transcriptional regulator ExsA
    NP_250404.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      1857273..1858109
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_250404.1 exoenzyme S transcriptional regulator ExsA [Pseudomonas aeruginosa PAO1]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0D6I0W8
      Conserved Domains (1) summary
      COG2207
      Location:149 → 268
      AraC; AraC-type DNA-binding domain and AraC-containing proteins [Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P26993.2

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    Research Materials