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    clt cricklet [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 117300, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cltprovided by FlyBase
    Official Full Name
    crickletprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000326
    Locus tag
    Dmel_CG9858
    See related
    AllianceGenome:FB:FBgn0000326
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-57Fb; CG9858; Dmel\CG9858; Est-R
    Summary
    Enables serine hydrolase activity. Involved in male mating behavior. Is expressed in organism. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES5A (carboxylesterase 5A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See clt in Genome Data Viewer
    Location:
    57F4-57F4; 2-96 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21617061..21619079, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17504566..17506584, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43243 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Protein tyrosine phosphatase-ERK/Enhancer of Ras1 Neighboring gene mahjong Neighboring gene antisense RNA:CR42547

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cricklet: A locus regulating a number of adult functions of Drosophila melanogaster. Shirras AD, et al. Proc Natl Acad Sci U S A, 1989 Jun. PMID 16578845, Free PMC Article
    2. Stage-specific effects of candidate heterochronic genes on variation in developmental time along an altitudinal cline of Drosophila melanogaster. Mensch J, et al. PLoS One, 2010 Jun 18. PMID 20585460, Free PMC Article
    3. Identification of a juvenile hormone esterase gene by matching its peptide mass fingerprint with a sequence from the Drosophila genome project. Campbell PM, et al. Insect Biochem Mol Biol, 2001 Apr 27. PMID 11267890
    4. Only one esterase of Drosophila melanogaster is likely to degrade juvenile hormone in vivo. Crone EJ, et al. Insect Biochem Mol Biol, 2007 Jun. PMID 17517331
    5. PTP-ER, a novel tyrosine phosphatase, functions downstream of Ras1 to downregulate MAP kinase during Drosophila eye development. Karim FD, et al. Mol Cell, 1999 Jun. PMID 10394362

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carboxylesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables serine hydrolase activity HDA PubMed 
    Process Evidence Code Pubs
    involved_in male mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cricklet
    Names
    CG9858-PA
    JHE-related
    clt-PA
    NP_536784.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21617061..21619079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080523.4 → NP_536784.1  cricklet [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_536784.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2F4
      Related
      FBpp0071604
      Conserved Domains (1) summary
      pfam00135
      Location:22 → 543
      COesterase; Carboxylesterase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2F4 Q9W2F4

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