Nprl2 Nitrogen permease regulator-like 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Nprl2provided by FlyBase
Official Full Name: Nitrogen permease regulator-like 2provided by FlyBase
Primary source: FLYBASE:FBgn0030800
Locus tag: Dmel_CG9104
See related: AllianceGenome:FB:FBgn0030800
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9104; Dmel\CG9104; GATOR1; Nplr2; npr2; Npr2; NPR2; nprl; nprl2
Summary: Predicted to contribute to GTPase activator activity. Involved in several processes, including germline cell cycle switching, mitotic to meiotic cell cycle; negative regulation of TORC1 signaling; and negative regulation of cell size. Located in autolysosome and nucleus. Part of Seh1-associated complex. Is expressed in adult head and organism. Used to study familial focal epilepsy with variable foci 3. Human ortholog(s) of this gene implicated in familial focal epilepsy with variable foci 2. Orthologous to human NPRL2 (NPR2 like, GATOR1 complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (16882509..16884365, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (16776542..16778398, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

The TORC1 inhibitor Nprl2 protects age-related digestive function in Drosophila.
Title: The TORC1 inhibitor Nprl2 protects age-related digestive function in Drosophila.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to amino acid starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to amino acid starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived egg chamber formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in germline cell cycle switching, mitotic to meiotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TORC1 signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of positive regulation of triglyceride catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of GATOR1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GATOR1 complex	TAS Traceable Author Statement more info	PubMed
part_of Seh1-associated complex	IDA Inferred from Direct Assay more info	PubMed
part_of Seh1-associated complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in autolysosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in vacuolar membrane	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain