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    lama lamina ancestor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38610, updated on 17-Dec-2024

    Summary

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    Official Symbol
    lamaprovided by FlyBase
    Official Full Name
    lamina ancestorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0016031
    Locus tag
    Dmel_CG10645
    See related
    AllianceGenome:FB:FBgn0016031
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10645; Dmel\CG10645
    Summary
    Predicted to enable phospholipase activity. Involved in dorsal appendage formation and imaginal disc development. Located in extracellular region. Is expressed in several structures, including CNS glial cell; adult brain cell body rind; ectoderm anlage; embryonic anal pad; and larval imaginal tissue. Orthologous to several human genes including PLBD2 (phospholipase B domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See lama in Genome Data Viewer
    Location:
    64C12-64C13; 3-13 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5343619..5355923, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5336719..5349023, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45742 Neighboring gene transfer RNA:Serine-AGA 2-5 Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Valine-TAC 1-1 Neighboring gene transfer RNA:Valine-TAC 1-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of phospholipase B from Dictyostelium discoideum reveals a new lipase family present in mammals, flies and nematodes, but not yeast. Morgan CP, et al. Biochem J, 2004 Sep 1. PMID 15193148, Free PMC Article
    2. Molecular and genetic analyses of lama, an evolutionarily conserved gene expressed in the precursors of the Drosophila first optic ganglion. Perez SE, et al. Mech Dev, 1996 Sep. PMID 8892229
    3. Integration of JAK/STAT receptor-ligand trafficking, signalling and gene expression in Drosophila melanogaster cells. Moore R, et al. J Cell Sci, 2020 Oct 12. PMID 32917740
    4. glial cells missing and gcm2 cell autonomously regulate both glial and neuronal development in the visual system of Drosophila. Chotard C, et al. Neuron, 2005 Oct 20. PMID 16242405
    5. Body size in Drosophila: genetic architecture, allometries and sexual dimorphism. Carreira VP, et al. Heredity (Edinb), 2009 Mar. PMID 19018274

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phospholipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dorsal appendage formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lamina ancestor
    Names
    CG10645-PA
    CG10645-PB
    CG10645-PC
    CG10645-PD
    lama-PA
    lama-PB
    lama-PC
    lama-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5343619..5355923 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168116.2 → NP_729060.2  lamina ancestor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729060.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1I2, Q8IH16, Q94898, Q9VRK8
      UniProtKB/TrEMBL
      I0E2J7
      Related
      FBpp0076862
      Conserved Domains (1) summary
      pfam04916
      Location:19 → 654
      Phospholip_B; Phospholipase B

    2. NM_079209.3 → NP_523933.3  lamina ancestor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523933.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1I2, Q8IH16, Q94898, Q9VRK8
      UniProtKB/TrEMBL
      I0E2J7
      Related
      FBpp0076863
      Conserved Domains (1) summary
      pfam04916
      Location:19 → 654
      Phospholip_B; Phospholipase B

    3. NM_001274511.1 → NP_001261440.1  lamina ancestor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261440.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1I2, Q8IH16, Q94898, Q9VRK8
      UniProtKB/TrEMBL
      I0E2J7
      Conserved Domains (1) summary
      pfam04916
      Location:19 → 654
      Phospholip_B; Phospholipase B

    4. NM_168115.2 → NP_729059.2  lamina ancestor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729059.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1I2, Q8IH16, Q94898, Q9VRK8
      UniProtKB/TrEMBL
      I0E2J7
      Related
      FBpp0076864
      Conserved Domains (1) summary
      pfam04916
      Location:19 → 654
      Phospholip_B; Phospholipase B
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    I0E2J7 I0E2J7
    Q9VRK8.3 Q9VRK8

    Gene LinkOut

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