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    Klc Kinesin light chain [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39445, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Klcprovided by FlyBase
    Official Full Name
    Kinesin light chainprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010235
    Locus tag
    Dmel_CG5433
    See related
    AllianceGenome:FB:FBgn0010235
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5433; DKLC; Dmel\CG5433; kinesin; Kinesin; klc; KLC
    Summary
    Predicted to enable kinesin binding activity. Involved in dorsal appendage formation and microtubule-based movement. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; ganglia; gut section; and larval muscle cell. Used to study Alzheimer's disease 1. Human ortholog(s) of this gene implicated in Alzheimer's disease; SPOAN syndrome; and relapsing-remitting multiple sclerosis. Orthologous to several human genes including KLC1 (kinesin light chain 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Klc in Genome Data Viewer
    Location:
    69E1-69E1; 3-39 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12746616..12750056, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12739716..12743156, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Protein tyrosine phosphatase 69D Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Vacuolar protein sorting 13D Neighboring gene Huntingtin interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tetratrico peptide repeats are present in the kinesin light chain. Gindhart JG Jr, et al. Trends Biochem Sci, 1996 Feb. PMID 8851660
    2. Kinesin: the tail unfolds. Cross R, et al. Nat Cell Biol, 1999 Sep. PMID 10559950
    3. Heterogeneity in kinesin function. Reddy BJN, et al. Traffic, 2017 Oct. PMID 28731566, Free PMC Article
    4. Kinetics of nucleotide-dependent structural transitions in the kinesin-1 hydrolysis cycle. Mickolajczyk KJ, et al. Proc Natl Acad Sci U S A, 2015 Dec 29. PMID 26676576, Free PMC Article
    5. Kinesin delivers: identifying receptors for motor proteins. Hollenbeck PJ. J Cell Biol, 2001 Mar 5. PMID 11238467, Free PMC Article

    See all (143) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kinesin-1 patterns Par-1 and Rho signaling at the cortex of syncytial embryos of Drosophila.
      Title: Kinesin-1 patterns Par-1 and Rho signaling at the cortex of syncytial embryos of Drosophila.
    2. Data show that kinesin-1 spends half of each stepping cycle with one head bound, specifying a structural state for each of two rate-limiting transitions.
      Title: Kinetics of nucleotide-dependent structural transitions in the kinesin-1 hydrolysis cycle.
    3. ensconsin promotes productive recruitment of Kinesin-1 to microtubules
      Title: Drosophila ensconsin promotes productive recruitment of Kinesin-1 to microtubules.
    4. A functional consequence of myosin V's diffusion on microtubules is a significant enhancement of the processive run length of kinesin when both motors are present on the same cargo.
      Title: Myosin V and Kinesin act as tethers to enhance each others' processivity.
    5. Data show that kinesin heavy chain can function independently of the light chain in the oocyte, indicating that it associates with its cargoes by a novel mechanism.
      Title: Kinesin light chain-independent function of the Kinesin heavy chain in cytoplasmic streaming and posterior localisation in the Drosophila oocyte.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables kinesin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dorsal appendage formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of kinesin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kinesin light chain
    Names
    CG5433-PA
    CG5433-PB
    CG5433-PC
    Klc-PA
    Klc-PB
    Klc-PC
    kinesin
    kinesin 1 light chain
    kinesin I
    kinesin light chain subunit of kinesin-1
    kinesin-1
    kinesin-1 light chain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12746616..12750056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079325.3 → NP_524049.1  kinesin light chain, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524049.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P46824, Q9VU05
      UniProtKB/TrEMBL
      M9PF24
      Related
      FBpp0075683
      Conserved Domains (2) summary
      sd00006
      Location:270 → 298
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:269 → 344
      TPR_12; Tetratricopeptide repeat

    2. NM_001274852.1 → NP_001261781.1  kinesin light chain, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261781.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFG7
      Conserved Domains (2) summary
      sd00006
      Location:270 → 298
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:269 → 344
      TPR_12; Tetratricopeptide repeat

    3. NM_001274851.1 → NP_001261780.1  kinesin light chain, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261780.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P46824, Q9VU05
      UniProtKB/TrEMBL
      M9PF24
      Conserved Domains (2) summary
      sd00006
      Location:270 → 298
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:269 → 344
      TPR_12; Tetratricopeptide repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PF24 M9PF24
    M9PFG7 M9PFG7
    P46824.1 P46824

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