vig vasa intronic gene [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: vigprovided by FlyBase
Official Full Name: vasa intronic geneprovided by FlyBase
Primary source: FLYBASE:FBgn0024183
Locus tag: Dmel_CG4170
See related: AllianceGenome:FB:FBgn0024183
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BG:DS00929.13; CG4170; Dmel\CG4170; EP(2)0812; Vig; VIG
Summary: Predicted to enable mRNA binding activity. Involved in heterochromatin organization and regulatory ncRNA-mediated post-transcriptional gene silencing. Located in cytoplasm; nucleus; and polytene chromosome puff. Part of RISC complex. Is expressed in several structures, including embryonic/larval midgut primordium; gut section; mesoderm; muscle cell; and visceral muscle primordium. Orthologous to several human genes including SERBP1 (SERPINE1 mRNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (15062931..15070316, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (15062931..15070316, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Vig binds and regulates core histone H2A and H3 mRNA via interaction with their 3' UTRs.
Title: dCas9-targeted locus-specific protein isolation method identifies histone gene regulators.
Fragile X-related protein and VIG associate with the RNA interference machinery
Title: Fragile X-related protein and VIG associate with the RNA interference machinery.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISM Inferred from Sequence Model more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in heterochromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of RISC complex	IDA Inferred from Direct Assay more info	PubMed
part_of RISC complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome puff	IDA Inferred from Direct Assay more info	PubMed

Names: CG4170-PA; CG4170-PB; CG4170-PC; CG4170-PD; vig-PA; vig-PB; vig-PC; vig-PD

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The following sections contain reference sequences that belong to a specific genome build. Explain