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    Dus4 Dihydrouridine synthase 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35179, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dus4provided by FlyBase
    Official Full Name
    Dihydrouridine synthase 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0032750
    Locus tag
    Dmel_CG10495
    See related
    AllianceGenome:FB:FBgn0032750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.200; CG10495; Dmel\CG10495
    Summary
    Predicted to enable tRNA-dihydrouridine20a synthase activity and tRNA-dihydrouridine20b synthase activity. Predicted to be involved in tRNA processing. Is expressed in organism. Orthologous to human DUS4L (dihydrouridine synthase 4 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dus4 in Genome Data Viewer
    Location:
    37B13-37B13; 2-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19063295..19064726)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19063295..19064726)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene PH domain leucine-rich repeat protein phosphatase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA dihydrouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA dihydrouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-dihydrouridine20a synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tRNA-dihydrouridine20b synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dihydrouridine synthase 4
    Names
    CG10495-PA
    Dus4-PA
    NP_609939.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19063295..19064726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136095.3 → NP_609939.1  dihydrouridine synthase 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609939.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJ06
      Related
      FBpp0080694
      Conserved Domains (2) summary
      cd02801
      Location:26 → 251
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      pfam01207
      Location:28 → 321
      Dus; Dihydrouridine synthase (Dus)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJ06 Q9VJ06

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