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    Tdg Thymine DNA glycosylase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43796, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tdgprovided by FlyBase
    Official Full Name
    Thymine DNA glycosylaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026869
    Locus tag
    Dmel_CG1981
    See related
    AllianceGenome:FB:FBgn0026869
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1981; CG1981; Dmel\CG1981; dmThd1p; G/T-mismatch-specific-thymine-DNA-glycosylase; MUG; TDG; thd1; Thd1; THD1; UDG_DM_7304305
    Summary
    Enables G/U mismatch-specific uracil-DNA glycosylase activity and double-stranded DNA binding activity. Involved in mismatch repair. Predicted to be active in nucleus. Is expressed in dorsal pharyngeal muscle cell; larval muscle system; and organism. Orthologous to human TDG (thymine DNA glycosylase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tdg in Genome Data Viewer
    Location:
    102C4-102C5; 4-0 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (538332..557854, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (559500..578480, complement)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45126 Neighboring gene TBP-associated factor 3 Neighboring gene uncharacterized protein Neighboring gene asator Neighboring gene Zn finger homeodomain 2 Neighboring gene long non-coding RNA:CR43958 Neighboring gene Purine-rich binding protein-alpha Neighboring gene NADH dehydrogenase (ubiquinone) 49 kDa subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Uracil-DNA glycosylase in insects. Drosophila and the locust. Morgan AR, et al. J Biol Chem, 1989 Jun 15. PMID 2722884
    2. A DNA glycosylase for oxidized thymine residues in Drosophila melanogaster. Breimer LH. Biochem Biophys Res Commun, 1986 Jan 14. PMID 3004428
    3. The versatile thymine DNA-glycosylase: a comparative characterization of the human, Drosophila and fission yeast orthologs. Hardeland U, et al. Nucleic Acids Res, 2003 May 1. PMID 12711670, Free PMC Article
    4. Physiological truncation and domain organization of a novel uracil-DNA-degrading factor. Pukáncsik M, et al. FEBS J, 2010 Mar. PMID 20121948
    5. Drosophila proteins involved in metabolism of uracil-DNA possess different types of nuclear localization signals. Merényi G, et al. FEBS J, 2010 May. PMID 20412059

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c541905-541776 mobile_element_type = transposon:INE-1{}5981
    • Loc: c543307-543142 mobile_element_type = transposon:INE-1{}5983
    • Loc: c543382-543308 mobile_element_type = transposon:INE-1{}6001
    • Loc: c543724-543383 mobile_element_type = transposon:INE-1{}6002
    • Loc: c544682-544350 mobile_element_type = transposon:INE-1{}6003
    • Loc: c549176-548817 mobile_element_type = transposon:INE-1{}6005

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G/U mismatch-specific uracil-DNA glycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mismatch base pair DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyrimidine-specific mismatch base pair DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uracil DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in base-excision repair, AP site formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in base-excision repair, AP site formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mismatch repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    thymine DNA glycosylase
    Names
    CG1981-PA
    CG1981-PB
    CG1981-PC
    TDG homolog of D.melanogaster
    Tdg-PA
    Tdg-PB
    Tdg-PC
    Thd1
    mismatch-specific uracil DNA glycosylase
    thymine-DNA glycosylase
    uracil-DNA glycosylase
    NP_001259060.1
    NP_001284715.1
    NP_651925.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      538332..557854 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297786.2 → NP_001284715.1  thymine DNA glycosylase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284715.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V4D8
      Conserved Domains (1) summary
      cl00483
      Location:714 → 962
      UDG_like; Uracil-DNA glycosylases (UDG) and related enzymes

    2. NM_001272131.2 → NP_001259060.1  thymine DNA glycosylase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259060.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V4D8
      Conserved Domains (1) summary
      cl00483
      Location:714 → 962
      UDG_like; Uracil-DNA glycosylases (UDG) and related enzymes

    3. NM_143668.3 → NP_651925.1  thymine DNA glycosylase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651925.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V4D8
      Related
      FBpp0088175
      Conserved Domains (1) summary
      cl00483
      Location:714 → 962
      UDG_like; Uracil-DNA glycosylases (UDG) and related enzymes
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V4D8 Q9V4D8
    Q9XYZ3 Q9XYZ3

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