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    Gbeta76C G protein beta subunit 76C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40148, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gbeta76Cprovided by FlyBase
    Official Full Name
    G protein beta subunit 76Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004623
    Locus tag
    Dmel_CG8770
    See related
    AllianceGenome:FB:FBgn0004623
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8770; DGqbeta; Dmel\CG8770; eGbeta; eye Gbeta; Galpha76C; gbe; Gbe; Gbeta; Gbeta76c; Gbetae; Gbeta[[e]]; Gbeta_76C; Gbeta{e}; Gqbeta; Gqbetae; G[q]; G[[beta76C]]; G[[beta]]; G[[beta]]e
    Summary
    Enables phospholipase activator activity and protein heterodimerization activity. Involved in negative regulation of smoothened signaling pathway and phospholipase C-activating opsin-mediated signaling pathway. Located in cytoplasm and rhabdomere. Part of heterotrimeric G-protein complex. Is expressed in Johnston organ; adult head; photoreceptor; photoreceptor neurons; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Gbeta76C in Genome Data Viewer
    Location:
    76C1-76C1; 3-46 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19687637..19689992)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19680737..19683092)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44678 Neighboring gene uncharacterized protein Neighboring gene vermiform Neighboring gene serpentine

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An eye-specific G beta subunit essential for termination of the phototransduction cascade. Dolph PJ, et al. Nature, 1994 Jul 7. PMID 8015606
    2. Excess of Gbetae over Gqalphae in vivo prevents dark, spontaneous activity of Drosophila photoreceptors. Elia N, et al. J Cell Biol, 2005 Nov 7. PMID 16260498, Free PMC Article
    3. Phospholipase C-mediated suppression of dark noise enables single-photon detection in Drosophila photoreceptors. Katz B, et al. J Neurosci, 2012 Feb 22. PMID 22357856, Free PMC Article
    4. In situ assay of light-stimulated G protein activity in Drosophila photoreceptor G protein beta mutants. Yarfitz SL, et al. J Biol Chem, 1994 Dec 2. PMID 7982946
    5. The importance of G-protein beta lambda subunits. Iñiguez-Lluhi J, et al. Trends Cell Biol, 1993 Jul. PMID 14731758

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phospholipase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor complex adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of opsin-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of smoothened signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phospholipase C-activating opsin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phospholipase C-activating opsin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototransduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in rhabdomere IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in rhabdomere TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G protein beta subunit 76C
    Names
    CG8770-PA
    G protein beta-subunit 76C
    G[[beta]] eye
    Gbeta76C-PA
    guanine nucleotide regulatory protein beta subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19687637..19689992
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078996.3 → NP_523720.2  G protein beta subunit 76C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523720.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P29829, Q9VW29
      Related
      FBpp0074717
      Conserved Domains (3) summary
      COG2319
      Location:45 → 345
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:51 → 345
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:64 → 99
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29829.3 P29829

    Gene LinkOut

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