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    st scarlet [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39836, updated on 17-Dec-2024

    Summary

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    Official Symbol
    stprovided by FlyBase
    Official Full Name
    scarletprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003515
    Locus tag
    Dmel_CG4314
    See related
    AllianceGenome:FB:FBgn0003515
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4314; Dmel\CG4314; DmScarlet; ST
    Summary
    Enables amine transmembrane transporter activity. Involved in aminergic neurotransmitter loading into synaptic vesicle; eye pigment precursor transport; and transmembrane transport. Located in pigment granule membrane. Is expressed in Bolwig organ; Malpighian tubule main body primordium; Malpighian tubule primordium; adult head; and embryonic Malpighian tubule. Used to study neurodegenerative disease. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    73A3-73A3; 3-44 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16497651..16500460)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16490751..16493560)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene argos Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. α-Synuclein pathology in Drosophila melanogaster is exacerbated by haploinsufficiency of Rop: connecting STXBP1 encephalopathy with α-synucleinopathies. Matsuoka T, et al. Hum Mol Genet, 2024 Jul 22. PMID 38692286
    2. Molecular characterization of spontaneous mutations at the scarlet locus of Drosophila melanogaster. ten Have JF, et al. Mol Gen Genet, 1995 Dec 20. PMID 8544833
    3. Reproductive behavior and fitness components in male Drosophila melaogaster are non-linearly affected by the number of male co-inhabitants early in adult life. Nandy B, et al. J Insect Sci, 2011. PMID 21867434, Free PMC Article
    4. The ommochrome biosynthetic pathway in Drosophila melanogaster: the head particulate phenoxazinone synthase and the developmental onset of xanthommatin synthesis. Yamamoto M, et al. Biochem Genet, 1976 Dec. PMID 828051
    5. Isolation and biochemical analysis of a temperature-sensitive scarlet eye color mutant of Drosophila melanogaster. Howells AJ. Biochem Genet, 1979 Feb. PMID 110313

    See all (144) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aminergic neurotransmitter loading into synaptic vesicle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eye pigment precursor transport IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in eye pigment precursor transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in pigment granule membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    scarlet
    Names
    CG4314-PA
    st-PA
    NP_524108.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16497651..16500460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079384.5 → NP_524108.1  scarlet [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524108.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P45843, Q6NP00, Q6NR69, Q9VV67
      UniProtKB/TrEMBL
      S5M3P7
      Related
      FBpp0075149
      Conserved Domains (3) summary
      cd03213
      Location:66 → 298
      ABCG_EPDR; Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily
      TIGR00955
      Location:67 → 665
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
      pfam01061
      Location:395 → 600
      ABC2_membrane; ABC-2 type transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P45843.3 P45843

    Gene LinkOut

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    Chemical Information
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