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    Fmo-1 Flavin-containing monooxygenase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37814, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fmo-1provided by FlyBase
    Official Full Name
    Flavin-containing monooxygenase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0034943
    Locus tag
    Dmel_CG3006
    See related
    AllianceGenome:FB:FBgn0034943
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3006; Dmel\CG3006; DmFMO-1; Dmfmo1; FMO-1
    Summary
    Enables monooxygenase activity. Located in cytosol and mitochondrion. Is expressed in embryonic/larval fat body; embryonic/larval midgut; and yolk nucleus. Human ortholog(s) of this gene implicated in hypertension; inherited metabolic disorder; and trimethylaminuria. Orthologous to several human genes including FMO1 (flavin containing dimethylaniline monoxygenase 1); FMO3 (flavin containing dimethylaniline monoxygenase 3); and FMO5 (flavin containing dimethylaniline monoxygenase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fmo-1 in Genome Data Viewer
    Location:
    60A14-60A14; 2-105 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23962956..23964641)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19850479..19852164)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene thoc5 Neighboring gene uncharacterized protein Neighboring gene alpha-catenin related Neighboring gene uncharacterized protein Neighboring gene Aminolevulinate synthase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Catalytic activity and expression of two flavin-containing monooxygenases from Drosophila melanogaster. Scharf ME, et al. Arch Insect Biochem Physiol, 2004 Sep. PMID 15352153
    2. Effects of methimazole on Drosophila glucolipid metabolism in vitro and in vivo. Wei Q, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2017 Jun. PMID 28341216
    3. δ-Aminolevulinate synthase is required for apical transcellular barrier formation in the skin of the Drosophila larva. Shaik KS, et al. Eur J Cell Biol, 2012 Mar. PMID 22293958
    4. The THO complex is required for nucleolar integrity in Drosophila spermatocytes. Moon S, et al. Development, 2011 Sep. PMID 21828100
    5. Serotonin and dopamine modulate aging in response to food odor and availability. Miller HA, et al. Nat Commun, 2022 Jun 7. PMID 35672307, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables N,N-dimethylaniline monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Flavin-containing monooxygenase 1
    Names
    CG3006-PA
    Fmo-1-PA
    NP_611859.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23962956..23964641
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138015.4 → NP_611859.1  Flavin-containing monooxygenase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611859.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q962N6, Q9W1E9
      Related
      FBpp0072059
      Conserved Domains (1) summary
      cl21454
      Location:5 → 197
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q962N6 Q962N6
    Q9W1E9 Q9W1E9

    Gene LinkOut

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