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    salt salty dog [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43742, updated on 9-Dec-2024

    Summary

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    Official Symbol
    saltprovided by FlyBase
    Official Full Name
    salty dogprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039872
    Locus tag
    Dmel_CG2196
    See related
    AllianceGenome:FB:FBgn0039872
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2196; Dmel\CG2196; dSLC5A7
    Summary
    Predicted to enable symporter activity. Predicted to be involved in sodium ion transport. Located in basolateral plasma membrane. Is expressed in Malpighian tubule Type I cell; adult Malpighian tubule; adult head; and adult main segment of Malpighian tubule. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A12 (solute carrier family 5 member 12); SLC5A5 (solute carrier family 5 member 5); and SLC5A8 (solute carrier family 5 member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See salt in Genome Data Viewer
    Location:
    100D2-100D2; 3-102 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31751825..31754705, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27577547..27580427, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene abnormal wing discs Neighboring gene nero Neighboring gene uncharacterized protein Neighboring gene mir-1014 stem loop Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44263

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    salty dog
    Names
    CG2196-PB
    CG2196-PC
    salt-PB
    salt-PC
    salty

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31751825..31754705 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300697.1 → NP_001287626.1  salty dog, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287626.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHY2, Q95SK1
      Conserved Domains (1) summary
      cd11492
      Location:28 → 565
      SLC5sbd_NIS-SMVT; Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain

    2. NM_143632.4 → NP_651889.3  salty dog, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651889.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SK1, Q9V9U2
      Conserved Domains (1) summary
      cd11492
      Location:28 → 566
      SLC5sbd_NIS-SMVT; Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHY2 A0A0B4LHY2
    Q95SK1 Q95SK1
    Q9V9U2 Q9V9U2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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