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    brun brunelleschi [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35325, updated on 9-Dec-2024

    Summary

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    Official Symbol
    brunprovided by FlyBase
    Official Full Name
    brunelleschiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261787
    Locus tag
    Dmel_CG2478
    See related
    AllianceGenome:FB:FBgn0261787
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    38D.28; bru; CG2478; Dmel\CG2478; dTRAPPC9; TRAPPC9
    Summary
    Involved in cytoskeleton-dependent cytokinesis; meiotic spindle organization; and spermatocyte division. Located in acroblast. Part of TRAPPII protein complex. Is expressed in adult head and organism. Used to study attention deficit hyperactivity disorder. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 13. Orthologous to human TRAPPC9 (trafficking protein particle complex subunit 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See brun in Genome Data Viewer
    Location:
    38D2-38D2; 2-54 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20650755..20656178, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20650755..20656178, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene U snoRNA host gene 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45004

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Contribution of Intellectual Disability-Related Genes to ADHD Risk and to Locomotor Activity in Drosophila. Klein M, et al. Am J Psychiatry, 2020 Jun 1. PMID 32046534
    2. Lost in translation gets an oskar. Hazelrigg T. Dev Cell, 2004 May. PMID 15130485
    3. Parcas is the predominant Rab11-GEF for rhodopsin transport in Drosophila photoreceptors. Otsuka Y, et al. J Cell Sci, 2019 Aug 7. PMID 31296556
    4. Cryo-EM structure of metazoan TRAPPIII, the multi-subunit complex that activates the GTPase Rab1. Galindo A, et al. EMBO J, 2021 Jun 15. PMID 34018214, Free PMC Article
    5. The roles of the oncoprotein GOLPH3 in contractile ring assembly and membrane trafficking during cytokinesis. Sechi S, et al. Biochem Soc Trans, 2015 Feb. PMID 25619256

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Trappc9 knockdown in circadian neurons resulted in increased locomotor activity and reduced sleep, concordant with the human phenotype of ADHD.
      Title: Contribution of Intellectual Disability-Related Genes to ADHD Risk and to Locomotor Activity in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in Golgi vesicle transport IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in actomyosin contractile ring contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in male meiosis cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiosis I cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiosis II cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatocyte division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TRAPP complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of TRAPPII protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in acroblast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    brunelleschi
    Names
    CG2478-PA
    brun-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      20650755..20656178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136200.3 → NP_610044.2  brunelleschi [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610044.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3KN61, Q961K0, Q9VIL0
      UniProtKB/TrEMBL
      U3PV94
      Related
      FBpp0080933
      Conserved Domains (1) summary
      pfam08626
      Location:42 → 1238
      TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VIL0.2 Q9VIL0

    Gene LinkOut

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