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    NAT1 NAT1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46020, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NAT1provided by FlyBase
    Official Full Name
    NAT1provided by FlyBase
    Primary source
    FLYBASE:FBgn0010488
    Locus tag
    Dmel_CG3845
    See related
    AllianceGenome:FB:FBgn0010488
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3845; Dmel\CG3845; dNAT1; l(2)01424; Nat1
    Summary
    Predicted to enable mRNA binding activity and translation initiation factor activity. Involved in chaeta development. Predicted to be part of eukaryotic translation initiation factor 4F complex. Is expressed in several structures, including adult central complex; adult head; brain; embryonic/larval salivary gland; and imaginal disc. Orthologous to human EIF4G2 (eukaryotic translation initiation factor 4 gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See NAT1 in Genome Data Viewer
    Location:
    49E1-49E1; 2-67 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12915994..12923734)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8803499..8811239)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46336 Neighboring gene long non-coding RNA:CR46337 Neighboring gene long non-coding RNA:CR44461 Neighboring gene uncharacterized protein Neighboring gene sugarbabe Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cellular mechanisms governing synaptic development in Drosophila melanogaster. Keshishian H, et al. J Neurobiol, 1993 Jun. PMID 8251016
    2. Drosophila NAT1, a homolog of the vertebrate translational regulator NAT1/DAP5/p97, is required for embryonic germband extension and metamorphosis. Yoshikane N, et al. Dev Growth Differ, 2007 Sep. PMID 17716306
    3. RNA-binding protein Nocte regulates Drosophila development by promoting translation reinitiation on mRNAs with long upstream open reading frames. Zhang T, et al. Nucleic Acids Res, 2024 Jan 25. PMID 38000373, Free PMC Article
    4. Evolutionarily conserved non-AUG translation initiation in NAT1/p97/DAP5 (EIF4G2). Takahashi K, et al. Genomics, 2005 Mar. PMID 15718103
    5. Dissecting the roles of EIF4G homologs reveals DAP5 as a modifier of CGG repeat-associated toxicity in a Drosophila model of FXTAS. Malik I, et al. Neurobiol Dis, 2023 Aug. PMID 37352983, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaeta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NAT1
    Names
    CG3845-PA
    CG3845-PB
    CG3845-PD
    NAT1-PA
    NAT1-PB
    NAT1-PD
    lethal (2) 01424
    NP_001033943.2
    • non-AUG (AUU) translation initiation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12915994..12923734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165961.2 → NP_725242.1  NAT1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725242.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E996, Q86NR8
      Related
      FBpp0086899
      Conserved Domains (4) summary
      cd11559
      Location:744 → 890
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      smart00544
      Location:558 → 671
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
      pfam02854
      Location:1 → 173
      MIF4G; MIF4G domain
      pfam15320
      Location:247 → 295
      RAM; mRNA cap methylation, RNMT-activating mini protein

    2. NM_001038854.2 → NP_001033943.2  NAT1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033943.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z968, Q5KTT4
      Conserved Domains (4) summary
      cd11559
      Location:1314 → 1460
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      smart00544
      Location:1128 → 1241
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
      pfam02854
      Location:518 → 743
      MIF4G; MIF4G domain
      pfam15320
      Location:817 → 865
      RAM; mRNA cap methylation, RNMT-activating mini protein

    3. NM_143770.3 → NP_652027.2  NAT1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652027.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E996, Q86NR8
      Related
      FBpp0086900
      Conserved Domains (4) summary
      cd11559
      Location:744 → 890
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      smart00544
      Location:558 → 671
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
      pfam02854
      Location:1 → 173
      MIF4G; MIF4G domain
      pfam15320
      Location:247 → 295
      RAM; mRNA cap methylation, RNMT-activating mini protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z968 A1Z968
    Q0E996 Q0E996

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