ninaB neither inactivation nor afterpotential B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ninaBprovided by FlyBase
Official Full Name: neither inactivation nor afterpotential Bprovided by FlyBase
Primary source: FLYBASE:FBgn0002937
Locus tag: Dmel_CG9347
See related: AllianceGenome:FB:FBgn0002937
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0148162.1; anon-WO0148163.1; beta-diox; CG9347; Dmel\CG9347; DRPE65; RPE65
Summary: Enables carotenoid isomerooxygenase activity. Involved in isoprenoid metabolic process; phototransduction; and rhodopsin biosynthetic process. Is expressed in several structures, including Bolwig organ primordium; adult brain; adult head; photoreceptor; and retina. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 2; retinitis pigmentosa; retinitis pigmentosa 20; and retinitis pigmentosa 87. Orthologous to several human genes including BCO1 (beta-carotene oxygenase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (13700565..13703164)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (9526287..9528886)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables beta-carotene 15,15'-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carotenoid dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carotenoid isomerooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carotene catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in carotene metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phototransduction	TAS Traceable Author Statement more info	PubMed
involved_in phototransduction, UV	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction, visible light	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinal metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinal metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in rhodopsin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in rhodopsin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vitamin A biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in vitamin A biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vitamin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

NP_650307.2

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The following sections contain reference sequences that belong to a specific genome build. Explain