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    Mesh1 Metazoan SpoT homolog-1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43456, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mesh1provided by FlyBase
    Official Full Name
    Metazoan SpoT homolog-1provided by FlyBase
    Primary source
    FLYBASE:FBgn0039650
    Locus tag
    Dmel_CG11900
    See related
    AllianceGenome:FB:FBgn0039650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11900; Dmel\CG11900; Q9VAM9
    Summary
    Enables guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity. Involved in guanosine tetraphosphate catabolic process and response to starvation. Is expressed in organism. Orthologous to human HDDC3 (HD domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mesh1 in Genome Data Viewer
    Location:
    99A1-99A1; 3-98 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29201756..29202525, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25027478..25028247, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene julius seizure Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytochrome c1-like Neighboring gene long non-coding RNA::CR31044 Neighboring gene mir-279 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The regulation of ferroptosis by MESH1 through the activation of the integrative stress response. Lin CC, et al. Cell Death Dis, 2021 Jul 22. PMID 34294679, Free PMC Article
    2. Estimates of Rel(Seq), Mesh1, and SAH(Mex) Hydrolysis of (p)ppGpp and (p)ppApp by Thin Layer Chromatography and NADP/NADH Coupled Assays. Potrykus K, et al. Front Microbiol, 2020. PMID 33193211, Free PMC Article
    3. ppGpp functions as an alarmone in metazoa. Ito D, et al. Commun Biol, 2020 Nov 13. PMID 33188280, Free PMC Article
    4. Growth suppression by altered (p)ppGpp levels results from non-optimal resource allocation in Escherichia coli. Zhu M, et al. Nucleic Acids Res, 2019 May 21. PMID 30916318, Free PMC Article
    5. A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses. Sun D, et al. Nat Struct Mol Biol, 2010 Oct. PMID 20818390

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The regulation of ferroptosis by MESH1 through the activation of the integrative stress response.
      Title: The regulation of ferroptosis by MESH1 through the activation of the integrative stress response.
    2. we highlight the Mesh1 (p)ppGpp hydrolase from Drosophila melanogaster as a powerful genetic tool for interrogating bacterial (p)ppGpp physiology.
      Title: Growth suppression by altered (p)ppGpp levels results from non-optimal resource allocation in Escherichia coli.
    3. Mesh1, encoded by Q9VAM9, has an active site for ppGpp hydrolysis & a conserved His-Asp-box motif for Mn(2+) binding. Deletion slows growth, impairs starvation resistance, downregulates DNA/protein synthesis genes & upregulates stress genes.
      Title: A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in guanosine tetraphosphate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metazoan SpoT homolog-1
    Names
    CG11900-PA
    Mesh1-PA
    NP_651682.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29201756..29202525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143425.2 → NP_651682.1  metazoan SpoT homolog-1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651682.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VAM9
      Related
      FBpp0084776
      Conserved Domains (1) summary
      COG0317
      Location:13 → 147
      SpoT; (p)ppGpp synthase/hydrolase, HD superfamily [Signal transduction mechanisms, Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAM9.1 Q9VAM9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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