U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    DZIP1 DZIP1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42921, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    DZIP1provided by FlyBase
    Official Full Name
    DZIP1provided by FlyBase
    Primary source
    FLYBASE:FBgn0039201
    Locus tag
    Dmel_CG13617
    See related
    AllianceGenome:FB:FBgn0039201
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13617; Dmel\CG13617; dzip1; Dzip1
    Summary
    Predicted to be involved in cilium assembly. Located in ciliary basal body; ciliary transition zone; and dendrite. Human ortholog(s) of this gene implicated in mitral valve prolapse; polycystic kidney disease 5; and spermatogenic failure 47. Orthologous to several human genes including DZIP1L (DAZ interacting zinc finger protein 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See DZIP1 in Genome Data Viewer
    Location:
    96A5-96A5; 3-85 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24515278..24518128)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20341000..20343850)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene nicotinic Acetylcholine Receptor alpha2 Neighboring gene mir-1017 stem loop Neighboring gene nicotinic Acetylcholine Receptor beta2 Neighboring gene Protein phosphatase 1alpha at 96A Neighboring gene antisense RNA:CR44021 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Essential, overlapping and redundant roles of the Drosophila protein phosphatase 1 alpha and 1 beta genes. Kirchner J, et al. Genetics, 2007 May. PMID 17513890, Free PMC Article
    2. Cep131-Cep162 and Cby-Fam92 complexes cooperatively maintain Cep290 at the basal body and contribute to ciliogenesis initiation. Wu Z, et al. PLoS Biol, 2024 Mar. PMID 38442096, Free PMC Article
    3. Dzip1 and Fam92 form a ciliary transition zone complex with cell type specific roles in Drosophila. Lapart JA, et al. Elife, 2019 Dec 10. PMID 31821146, Free PMC Article
    4. Intergenerational Impact of Parental Zinc Deficiency on Metabolic and Redox Outcomes in Drosophila melanogaster. Sanusi KO, et al. Biology (Basel), 2024 Jun 1. PMID 38927281, Free PMC Article
    5. CEP290 is essential for the initiation of ciliary transition zone assembly. Wu Z, et al. PLoS Biol, 2020 Dec. PMID 33370260, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dzip1-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli/Ci proteins in the Hh pathway.
      Title: Stabilization of speckle-type POZ protein (Spop) by Daz interacting protein 1 (Dzip1) is essential for Gli turnover and the proper output of Hedgehog signaling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary transition zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    DZIP1
    Names
    CG13617-PA
    CG13617-PB
    DZIP1-PA
    DZIP1-PB
    iguana

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24515278..24518128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143006.2 → NP_651263.1  DZIP1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651263.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VC70
      Related
      FBpp0084025
      Conserved Domains (2) summary
      TIGR02169
      Location:182 → 457
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam13815
      Location:16 → 133
      Dzip-like_N; Iguana/Dzip1-like DAZ-interacting protein N-terminal

    2. NM_001275989.1 → NP_001262918.1  DZIP1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262918.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VC70
      Conserved Domains (2) summary
      TIGR02169
      Location:182 → 457
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam13815
      Location:16 → 133
      Dzip-like_N; Iguana/Dzip1-like DAZ-interacting protein N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VC70.1 Q9VC70

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools